Tonic activity of submucosal neurons influences basal ion transport.
Tonic activity of submucosal neurons influences basal ion transport.
复制标题
粘膜下神经元的强直活动影响基础离子转运。
DOI：
10.1016/0024-3205(89)90335-4
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发表时间：
1989
期刊：
影响因子：
6.1
通讯作者：
Cooke,HJ
中科院分区：
文献类型：
--
作者：
Carey,HV;Cooke,HJ
在流室中放置的豚鼠回肠薄片上，研究了紧张性活跃的粘膜下神经元对基础离子转运的影响。与对照组织相比，河豚毒素引起的短路电流立即持续下降，持续60分钟，而对照组组织的基础电流随着时间的推移逐渐下降。用阿托品治疗的组织的基础短路电流随时间的变化与对照组织没有显著差异。河豚毒素后短路电流的减少是由于净氯吸收比钠吸收的增加更大。钠和氯化物净转运的变化是由于这些离子的粘膜到浆膜通量的增加。结果提示，黏膜下神经元的紧张性活动限制了豚鼠回肠的吸收能力。
The influence of tonically active submucosal neurons on basal ion transport was studied using sheets of guinea pig ileum set up in flux chambers. Tetrodotoxin evoked an immediate and sustained decrease in short-circuit current that was sustained for 60 minutes compared with control tissues in which basal currents gradually decreased over time. Time-dependent changes in basal short-circuit currents in tissues treated with atropine were not significantly different from control tissues. The decrease in short-circuit current after tetrodotoxin resulted from a greater increase in net chloride absorption than sodium absorption. Changes in net sodium and chloride transport were due to an increase in the mucosal-to-serosal fluxes of these ions. The results suggest that tonic activity of submucosal neurons limits the absorptive capacity of the guinea pig ileum.