Neurological soft signs in first-episode psychosis: a systematic review
Neurological soft signs in first-episode psychosis: a systematic review
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DOI：
10.1192/bjp.181.43.s50
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发表时间：
2002-09-01
影响因子：
10.5
通讯作者：
Murray, RM
中科院分区：
文献类型：
--
作者：
Dazzan, P;Murray, RM
背景神经软征（NSS）是一种提示非特异性脑功能障碍的轻微神经系统体征。他们的存在已被广泛记录在精神分裂症，但不是在第一次精神病episode.Aims审查的研究，专门调查了NSS在第一次精神病episode.Method审查的研究调查神经功能在第一次精神病，使用临床examination.Results患者首次发作精神病显示出过度的NSS，特别是在运动协调和排序领域，感觉整合和发育反射。此外，NSS可能与一个特定的lateralitypatterns.Conclusions首发精神分裂症需要更多的研究，评估感觉和运动神经领域（评分分别为身体的两侧），整合这方面的知识与神经影像学的发现和澄清的作用，NSS作为标记的认知功能障碍。斯坦利基金会和医学研究理事会（英国）的资助。
Background Neurological soft signs (NSS) are minor neurological signs indicating non-specific cerebral dysfunction. Their presence has been documented extensively in schizophrenia but not during the first psychotic episode.Aims To review studies that have specifically investigated NSS at the time of the first psychotic episode.Method A review of studies investigating neurological function in first-episode psychosis, using a clinical examination.Results Patients with first-episode psychosis show an excess of NSS, particularly in the areas of motor coordination and sequencing, sensory integration and in developmental reflexes. Furthermore, NSS may be associated with a specific laterality pattern.Conclusions More studies on first-onset schizophrenia are needed, evaluating both sensory and motor neurological domains (scoring separately for the two sides of the body), integrating this knowledge with neuroimaging findings and clarifying the role of NSS as markers of cognitive dysfunction.Declaration of interest None. Funding from the Stanley Foundation and the Medical Research Council (UK).