RTOG GU RADIATION ONCOLOGY SPECIALISTS REACH CONSENSUS ON PELVIC LYMPH NODE VOLUMES FOR HIGH-RISK PROSTATE CANCER
RTOG GU RADIATION ONCOLOGY SPECIALISTS REACH CONSENSUS ON PELVIC LYMPH NODE VOLUMES FOR HIGH-RISK PROSTATE CANCER
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DOI：
10.1016/j.ijrobp.2008.08.002
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发表时间：
2009-06-01
影响因子：
7
通讯作者：
Seider, Michael
中科院分区：
文献类型：
--
作者：
Lawton, Colleen A. F.;Michalski, Jeff;Seider, Michael
目的：放射治疗肿瘤组（RTOG）的几项临床试验要求对高危前列腺癌患者的盆腔淋巴结进行放射治疗。根据以前的淋巴结轮廓显着分歧的定义，盆腔淋巴结体积之间的泌尿生殖放射肿瘤学专家参与开发和执行目前的RTOG trials.Materials和方法：2007年10月3日举行了一次共识会议，达成协议盆腔淋巴模式的体积。提供数据以解决前列腺淋巴结引流。广泛的讨论，随后发展临床靶体积（CTV）盆腔淋巴结consensus.Results：共识，得到了计算机断层扫描图像为基础的盆腔淋巴结CTVs。基于这一共识，待辐照的盆腔淋巴结体积包括：远端髂总淋巴结、骶前淋巴结（SI-SA）、髂外淋巴结、髂内淋巴结和闭孔淋巴结。淋巴结CTVs包括血管（动脉和静脉）和7 mm放射状边缘，小心地“切开”肠、膀胱、骨和肌肉。耻骨开始于L5/S1间隙，结束于耻骨的上级。剂量-体积直方图约束OARs的共识也achieved.Conclusions：盆腔淋巴结CTVs的放射治疗，以解决高风险前列腺癌的共识，并可作为基于网络的计算机断层扫描图像，以及通过RTOG的描述性格式。这将允许在评价这种治疗的获益和风险时保持一致。(C)2009 Elsevier Inc.
Purpose: Radiation therapy to the pelvic lymph nodes in high-risk prostate cancer is required on several Radiation Therapy Oncology Group (RTOG) clinical trials. Based on a prior lymph node contouring shown significant disagreement in the definition of pelvic lymph node volumes among genitourinary radiation oncology specialists involved in developing and executing current RTOG trials.Materials and Methods: A consensus meeting was held on October 3, 2007, to reach agreement on pelvic lymph mode volumes. Data were presented to address the lymph node drainage of the prostate. Extensive discussion ensued to develop clinical target volume (CTV) pelvic lymph node consensus.Results: Consensus was obtained resulting in computed tomography image-based pelvic lymph node CTVs. Based on this consensus, the pelvic lymph node volumes to be irradiated include: distal common iliac, presacral lymph nodes (SI-SA external iliac lymph nodes, internal iliac lymph nodes, and obturator lymph nodes. Lymph node CTVs include the vessels (artery and vein) and a 7-mm radial margin being careful to "carve out" bowel, bladder, bone, and muscle. Volumes begin at the L5/S1 interspace and end at the superior aspect of the pubic bone. Consensus on dose-volume histogram constraints for OARs was also attained.Conclusions: Consensus on pelvic lymph node CTVs for radiation therapy to address high-risk prostate cancer was attained and is available as web-based computed tomography images as well as a descriptive format through the RTOG. This will allow for uniformity in evaluating the benefit and risk of such treatment. (C) 2009 Elsevier Inc.