Cognitive impairment and medication adherence in outpatients with heart failure
Cognitive impairment and medication adherence in outpatients with heart failure
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DOI：
10.1016/j.hrtlng.2012.06.001
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发表时间：
2012-11-01
期刊：
影响因子：
2.8
通讯作者：
Silvet, Helme
中科院分区：
文献类型：
--
作者：
Hawkins, Lee Ann;Kilian, Shirley;Silvet, Helme
目的：研究目的是（a）描述患有心力衰竭（HF）的门诊退伍军人人群中认知损害（CI）的患病率和严重程度，（B）描述发现患有CI的受试者中受影响的认知领域，（c）检查可能与CI相关的临床和人口统计学变量，以及（d）确定CI与药物依从性（MA）之间的关系。我们假设CI是HF退伍军人的一种常见疾病，与MA较差相关。坚持治疗对成功的结果至关重要。CI可能会影响依从性，很少有人知道CI在退伍军人HF或CI对MA.METHODS的影响：我们招募了251名退伍军人HF门诊患者。对受试者进行CI筛查;通过药丸计数确定依从性。结果：58%的受试者存在无法识别的脑梗死。言语学习、即时记忆和延迟言语记忆受损最严重。CI与MA较差显著相关。与CI相关的变量包括年龄，非洲裔美国人的种族，抑郁症，使用酒精，和nonparticipation在pill count.CONCLUSION未识别的CI是普遍存在的，并与较差的MA。我们建议对HF患者进行CI的常规筛查。一、Kilian，S.，Firek，A.，Kashner，T. M.，菲尔克角J.，& Silvet，H. (2012（1999年11月至12月）。门诊心力衰竭患者的认知障碍与药物治疗依从性。Heart & Lung，41（6），572-582. http://dx.doi.org/10.1016/j.hrtlng.2012.06.001.
OBJECTIVES: The study objectives were (a) to describe the prevalence and severity of cognitive impairment (CI) in an outpatient veteran population with heart failure (HF), (b) to describe the cognitive domains affected in those subjects found to have CI, (c) to examine clinical and demographic variables that may be associated with CI, and (d) to determine the relationship between CI and medication adherence (MA). We hypothesized that CI is a prevalent condition in veterans with HF and is associated with poorer MA. Adherence to therapy is essential for successful outcomes. CI may affect adherence; little is known about CI in veterans with HF or the effect of CI on MA.METHODS: We enrolled 251 veteran outpatients with HF. Subjects were screened for CI; adherence was determined by pill counts. Subjects with CI underwent further neuropsychologic testing.RESULTS: Unrecognized CI was found in 58% of subjects. Verbal learning, immediate memory, and delayed verbal memory were most impaired. CI was significantly associated with poorer MA. Variables associated with CI included age, African-American race, depression, use of alcohol, and nonparticipation in pill count.CONCLUSION Unrecognized CI was prevalent and associated with poorer MA. We propose routine screening for CI in patients with HF.Cite this article: Hawkins, L. A., Kilian, S., Firek, A., Kashner, T. M., Firek, C. J., & Silvet, H. (2012, NOVEMBER-DECEMBER). Cognitive impairment and medication adherence in outpatients with heart failure. Heart & Lung, 41(6), 572-582. http://dx.doi.org/10.1016/j.hrtlng.2012.06.001.