Dysphagia in patients with inclusion body myositis
Dysphagia in patients with inclusion body myositis
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DOI：
10.1097/00005537-199807000-00009
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发表时间：
1998-07-01
期刊：
影响因子：
2.6
通讯作者：
Strome, M
中科院分区：
文献类型：
--
作者：
Houser, SM;Calabrese, LH;Strome, M
目的：包涵体肌炎 (IBM) 是一种炎症性肌病，据报道吞咽困难的发生率为 40%，病程迁延，药物治疗难治，经常需要咨询耳鼻喉科医生进行吞咽困难治疗。我们研究了 IBM 患者吞咽困难的发生率、症状和机制，研究设计：病历回顾性研究和自我报告的随访调查；吞咽困难被定义为吞咽困难。材料：22 名经活检证实的 IBM 患者。结果：吞咽困难发生率超过 80%（19 例中有 16 例），是之前报道的两倍。进行性吞咽困难与功能等级显着恶化相关，建立了相关的管理指南，包括适当手术干预的时机。结论：进行性吞咽困难可能意味着 IBM 更具攻击性或状态间歇性恶化。识别疾病表现将有助于对患者进行适当的管理。知情的耳鼻喉科医师可以对 IBM 相关的吞咽困难产生有利的影响。
Objectives: Inclusion body myositis (IBM) is an inflammatory myopathy with a 40% reported incidence of dysphagia, A protracted course, refractory to medical therapy, frequently leads to consultation with an otolaryngologist for dysphagia management, We studied the incidence, symptoms, and mechanisms of dysphagia in patients with IBM, Study Design: Retrospective study of medical records and self-reported follow-up survey; dysphagia is defined as difficulty in swallowing. Materials: Twenty-two patients with biopsy-proven IBM. Results: The rate of dysphagia was more than 80% (16 of 19), twice as high as previously reported. Progressive dysphagia was associated with a significantly worse functional class, Relevant management guidelines are established, including the timing for appropriate surgical intervention. Conclusion: Progressive dysphagia may signify more aggressive IBM or an episodic worsening in status. Recognition of the disease manifestations will afford proper patient management. Informed otolaryngologists can have a favorable impact on the dysphagia associated with IBM.