International trends in prostate-cancer mortality: the decrease is continuing and spreading
International trends in prostate-cancer mortality: the decrease is continuing and spreading
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DOI：
10.1023/b:caco.0000024212.66334.26
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发表时间：
2004-04-01
影响因子：
2.3
通讯作者：
Aitken, JF
中科院分区：
文献类型：
--
作者：
Baade, PD;Coory, MD;Aitken, JF
目的：衡量24个发达国家前列腺癌死亡率的近期变化。研究方法：年龄在50 - 79岁之间的男性死亡率数据来自世界卫生组织死亡率数据库，我们使用联合点回归模型评估了年龄标准化死亡率的趋势。结果如下：在英国，美国，奥地利，加拿大，意大利，法国，德国，澳大利亚和西班牙的前列腺癌死亡率显着下降，下降趋势也观察到在荷兰，爱尔兰和Sweden.Conclusions：前列腺癌的死亡率下降是显而易见的，现在在12的24个发达国家在本分析中考虑。PSA筛查的增加和早期疾病的更好治疗，可能联合作用，仍然是合理的假设。
Objective: To measure recent changes in prostate-cancer mortality across 24 developed countries. Methods: Mortality data for men aged 50 - 79 years were obtained from the World Health Organisation mortality database and we assessed trends in age-standardised mortality rates using joinpoint regression models. Results: Significant reductions in prostate-cancer mortality were observed in United Kingdom, United States, Austria, Canada, Italy, France, Germany, Australia and Spain, and downward trends were also observable in the Netherlands, Ireland and Sweden.Conclusions: Mortality declines for prostate cancer are now evident in 12 out of the 24 developed countries considered in this analysis. Increases in PSA screening and better treatment of early-stage disease, possibly acting in combination, remain plausible hypotheses.