Subjective memory complaints are associated with altered resting-state functional connectivity but not structural atrophy
Subjective memory complaints are associated with altered resting-state functional connectivity but not structural atrophy
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DOI：
10.1016/j.nicl.2019.101675
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Yamaguchi, Shuhei
中科院分区：
文献类型：
--
作者：
Kawagoe, Toshikazu;Onoda, Keiichi;Yamaguchi, Shuhei
研究表明，患有主观记忆主诉(SMC)的人会出现微妙的认知能力下降，并伴随着病理变化。然而，在认知变化显现之前，关于测量静息状态功能连接以检测神经退行性疾病中细微的脑网络变化的证据较少。我们调查了SMC与认知表现的相关性，并使用行为和脑成像数据驱动的方法，探索了SMC严重程度背后的脑功能和结构变化。我们观察到，SMC与抑郁有关，但与认知测试分数无关，这意味着SMC代表“焦虑良好”；然而，该模型仅解释了目标变量的15%。使用保守阈值，我们观察到舌回、楔状回、前岛和顶上小叶中与SMC严重程度相关的连通性。HOC后分析表明，随着SMC严重程度的增加，枕顶功能连通性增加。相比之下，体积改变与SMC无关，即使在应用自由阈值后也是如此。我们的发现表明，SMC相关区域静息状态功能连接的改变可能反映了认知和结构异常发展之前发生的早期代偿性变化。
Research indicates that a subtle cognitive decline, accompanied by pathological changes, occurs in individuals with subjective memory complaints (SMC). However, there is less evidence regarding the measurement of resting-state functional connectivity to detect subtle brain network alterations in neurodegenerative illnesses before cognitive change manifestation. We investigated the correlation between SMC and cognitive performance and explored functional and structural brain changes underlying SMC severity, using behavioral and brain imaging data-driven approaches. We observed that SMC was associated with depression but not with cognitive test scores, implying that SMC represent the "worried-well"; however, this model explains only 15% of the target variance. Using a conservative threshold, we observed connectivity related to SMC severity in the lingual gyrus, cuneus, anterior insula, and superior parietal lobule. Post-hoc analysis indicated that occipital and parietal functional connectivity increased with SMC severity. In contrast, volumetric alterations were not associated with SMC, even after applying a liberal threshold. Our findings suggest that altered resting-state functional connectivity in regions associated with SMC might reflect early compensatory changes that occur before cognitive and structural abnormalities develop.