In vivo osteoinductivity of gelatin β-tri-calcium phosphate sponge and bone morphogenetic protein-2 on an equine third metacarpal bone defect
In vivo osteoinductivity of gelatin β-tri-calcium phosphate sponge and bone morphogenetic protein-2 on an equine third metacarpal bone defect
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DOI：
10.1016/j.rvsc.2011.12.002
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发表时间：
2012-10-01
影响因子：
2.4
通讯作者：
Sasaki, N.
中科院分区：
文献类型：
--
作者：
Tsuzuki, N.;Otsuka, K.;Sasaki, N.
本研究评价了明胶-β-TCP海绵（海绵）结合BMP-2（BMP-2/海绵）对马骨再生的治疗效果。在五匹纯种马的第三掌骨中创建六个骨缺损，并以随机方式应用总共六种治疗。处理是BMP-2/海绵、BMP-2/明胶水凝胶片（片）、游离BMP-2、bFGF/片、普通海绵和普通片。通过X线摄影监测缺损16周，然后通过组织学分析进行检查。骨再生X线评分显示，BMP-2/海绵组骨缺损的骨再生明显高于单纯海绵组和BMP-2片组（P < 0.05）。在组织学分析中，在BMP-2/海绵处理中在大面积上观察到密质骨。我们的结论是，BMP-2/海绵治疗加速了本研究的马的骨再生。爱思唯尔有限公司出版
This study evaluated the therapeutic effects of a gelatin-beta-TCP sponge (sponge) incorporating BMP-2 (BMP-2/sponge) on bone regeneration in equines. Six bone defects were created in third metacarpals of five thoroughbred horses, and a total of six treatments were applied in a randomized manner. The treatments were BMP-2/sponge, BMP-2/gelatin hydrogel sheet (sheet), free BMP-2, bFGF/sheet, plain sponge, and plain sheet. The defects were monitored for 16 weeks by radiography and then examined by histological analysis. Radiographic evaluation scores of bone regeneration revealed significantly greater bone regeneration of defects treated with BMP-2/sponge than defects treated with plain sponge or BMP-2 sheet (P < 0.05). In histological analysis, compact bone was observed over a wide area in the BMP-2/sponge treatment. We concluded that the treatment with BMP-2/sponge accelerated bone regeneration in the equines of this study. Published by Elsevier Ltd.