The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in the Gambia
The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in the Gambia
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DOI：
10.1128/iai.72.10.6185-6189.2004
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发表时间：
2004-10-01
影响因子：
3.1
通讯作者：
Riley, EM
中科院分区：
文献类型：
--
作者：
Corran, PH;O'Donnell, RA;Riley, EM
在对187名冈比亚儿童和成人的横断面调查中，我们分析了患病率、精细特异性和19千道尔顿裂殖子表面蛋白1。（MSP-1（19））特异性红细胞侵入抑制活性，但发现这些参数中的任何一个与疟疾寄生虫血症的流行率或密度之间没有显著关联，除了，在校正总的抗MSP-1（19）抗体水平后，具有与侵袭抑制性单克隆抗体（12.10）竞争的抗MSP-1（19）抗体的个体比没有这种抗体的个体显著更不可能具有密度大于或等于1，000个寄生虫/穆尔的疟疾感染。这种关联在校正年龄和种族来源后仍然存在。
In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of greater than or equal to1,000 parasites/mul than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.