Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study
Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study
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DOI：
10.1038/npp.2017.48
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发表时间：
2017-07-01
影响因子：
7.6
通讯作者：
Mandelkern, Mark A.
中科院分区：
文献类型：
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作者：
Brody, Arthur L.;Hubert, Robert;Mandelkern, Mark A.
在大脑中，小胶质细胞不断扫描周围的细胞外空间，以便通过激活并参与神经炎症来应对损伤或感染。当激活时，小胶质细胞会增加易位蛋白 (TSPO) 18 kDa 的表达，从而使 TSPO 表达成为神经炎症的标志物。我们使用放射性示踪剂 [C-11] DAA1106（TSPO 的配体）和正电子发射断层扫描 (PET) 来确定吸烟对该神经炎症标记物可用性的影响。 45 名参与者（30 名吸烟者和 15 名非吸烟者）完成了研究并获得了可用数据。参与者接受动态 PET 扫描，其中推注 [C-11] DAA1106（吸烟者处于饱腹状态）并在 PET 扫描期间抽血以确定 TSPO 亲和力基因型和血浆尼古丁水平。确定全脑标准化摄取值（SUV），并进行方差分析，以群体（吸烟者与非吸烟者）和基因型为因素，从而控制基因型。吸烟者和非吸烟者在全脑 SUV 方面存在差异 (P = 0.006)，因为吸烟者的值比不吸烟者低 16.8%。各组在用于计算 SUV 的注射放射性示踪剂剂量或体重方面没有差异。全脑 SUV 与报告的每天吸烟量之间存在负相关关系（P
In the brain, microglia continuously scan the surrounding extracellular space in order to respond to damage or infection by becoming activated and participating in neuroinflammation. When activated, microglia increase the expression of translocator protein (TSPO) 18 kDa, thereby making the TSPO expression a marker for neuroinflammation. We used the radiotracer [C-11] DAA1106 (a ligand for TSPO) and positron emission tomography (PET) to determine the effect of smoking on availability of this marker for neuroinflammation. Forty-five participants (30 smokers and 15 non-smokers) completed the study and had usable data. Participants underwent a dynamic PET scanning session with bolus injection of [C-11] DAA1106 (with smokers in the satiated state) and blood draws during PET scanning to determine TSPO affinity genotype and plasma nicotine levels. Whole-brain standardized uptake values (SUVs) were determined, and analysis of variance was performed, with group (smoker vs non-smoker) and genotype as factors, thereby controlling for genotype. Smokers and non-smokers differed in whole-brain SUVs (P = 0.006) owing to smokers having 16.8% lower values than non-smokers. The groups did not differ in injected radiotracer dose or body weight, which were used to calculate SUV. An inverse association was found between whole-brain SUV and reported cigarettes per day (P