Whole-Brain Haemodynamic After-Effects of 1-Hz Magnetic Stimulation of the Posterior Superior Temporal Cortex During Action Observation
Whole-Brain Haemodynamic After-Effects of 1-Hz Magnetic Stimulation of the Posterior Superior Temporal Cortex During Action Observation
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DOI：
10.1007/s10548-012-0239-9
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发表时间：
2013-04-01
期刊：
影响因子：
2.7
通讯作者：
Cattaneo, Luigi
中科院分区：
文献类型：
--
作者：
Arfeller, Carola;Schwarzbach, Jens;Cattaneo, Luigi
后上级颞沟（pSTS）是活跃的，当观察生物运动。我们通过测量局灶重复经颅磁刺激（rTMS）与全脑功能磁共振成像（fMRI）的后效，研究了pSTS节点在动作观察网络中的功能连接。参与者在pSTS区域接受1Hz rTMS 10分钟，然后立即进行fMRI。在扫描过程中，他们观看了手抓住物体（抓取片段）或在物体旁边移动（控制片段）的短视频片段。对四个连续的块重复rTMS-fMRI。在两个区块中，我们刺激左侧pSTS区域，在另外两个区块中刺激右侧pSTS区域。对于每侧，以有效强度（运动阈值的95%）或无效强度（运动阈值的50%）应用TMS。在外侧颞枕叶皮层，前顶内区和腹侧运动前皮层中确定了显示（剪辑类型）9（TMS强度）的交互作用的大脑区域。rTMS的远程影响主要限于刺激半球，包括与对照夹相比，对抓握夹的血氧水平依赖性反应增加。我们发现，pSTS占据了一个关键的中继位置，在观察目标导向的行动。
The posterior superior temporal sulcus (pSTS) is active when observing biological motion. We investigated the functional connections of the pSTS node within the action observation network by measuring the aftereffect of focal repetitive transcranial magnetic stimulation (rTMS) with whole-brain functional magnetic resonance imaging (fMRI). Participants received 1-Hz rTMS over the pSTS region for 10 min and underwent fMRI immediately after. While scanned, they were shown short video clips of a hand grasping an object (grasp clips) or moving next to it (control clips). rTMS-fMRI was repeated for four consecutive blocks. In two blocks we stimulated the left pSTS region and in the other two the right pSTS region. For each side TMS was applied with an effective intensity (95 % of motor threshold) or with ineffective intensity (50 % of motor threshold). Brain regions showing interactive effects of (clip type) 9 (TMS intensity) were identified in the lateral temporo-occipital cortex, in the anterior intraparietal region and in the ventral premotor cortex. Remote effects of rTMS were mostly limited to the stimulated hemisphere and consisted in an increase of blood oxygen level-dependent responses to grasp clips compared to control clips. We show that the pSTS occupies a pivotal relay position during observation of goal-directed actions.