An interactive web site providing major histocompatibility ligand predictions: Application to HIV research
An interactive web site providing major histocompatibility ligand predictions: Application to HIV research
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DOI：
10.1089/aid.1997.13.529
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发表时间：
1997-05-01
影响因子：
1.5
通讯作者：
Deocampo, G
中科院分区：
文献类型：
--
作者：
DeGroot, AS;Jesdale, BM;Deocampo, G
EpiMatrix/HIV 是目前在万维网上可用的一种工具，它使研究人员能够筛选 HIV 蛋白中潜在的 MHC 配体。我们将 EpiMatrix 预测与源自 133 种蛋白质的 158 种同种异型特异性 HLA 相关肽（MHC 配体）进行了比较。选择 158 个 HLA 同种异型蛋白对中每对排名前 10 的 EpiMatrix 预测与这些已发表的配体进行比较，EpiMatrix 正确识别了 158 个已发表的配体中的 134 个 (85%)。该算法现在可供 HIV 研究界使用，网址为 http://www.EpiMatrix.com/HIV。
EpiMatrix/HIV, a tool that is currently available on the World Wide Web, enables researchers to screen HIV proteins for potential MHC ligands. We have performed a comparison of EpiMatrix predictions to 158 published allotype-specific HLA-associated peptides (MHC ligands) derived from 133 proteins. The top 10 ranked EpiMatrix predictions for each of the 158 HLA allotype-protein pairs were selected for comparison with these published ligands, EpiMatrix correctly identified 134 of 158 published ligands (85%). The algorithm is now available for use by the HIV research community at the URL http://www.EpiMatrix.com/HIV.