Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis.
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis.
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iNKT 细胞的发育程序化早期皮肤定位支持局部组织发育和稳态。
DOI：
10.1038/s41590-022-01399-5
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发表时间：
2023
影响因子：
30.5
通讯作者：
Xiong,Na
中科院分区：
文献类型：
--
作者：
Wang,Wei-Bei;Lin,Yang-Ding;Zhao,Luming;Liao,Chang;Zhang,Yang;Davila,Micha;Sun,Jasmine;Chen,Yidong;Xiong,Na
皮肤暴露于各种环境攻击，并在出生后立即发生形态变化。皮肤中免疫细胞的适当定位和功能对于保护和建立皮肤组织稳态至关重要。在这里，我们报告发现了一个发育编程的过程，指导优先本地化的不变的自然杀伤T（iNKT）细胞的皮肤早期局部稳态调节。我们发现，在婴儿和年轻小鼠的胸腺发育过程中，iNKT细胞主要以CCR 10+皮肤归巢表型编程。iNKT细胞的早期皮肤定位对于适当的细菌定植和组织发育至关重要。从机制上讲，皮肤iNKT细胞提供了转铁蛋白的局部来源，该转铁蛋白调节毛囊祖细胞中的铁代谢并帮助毛囊发育。这些发现为早期生命中皮肤中iNKT细胞的建立和生理功能提供了分子见解。
Skin is exposed to various environmental assaults and undergoes morphological changes immediately after birth. Proper localization and function of immune cells in the skin is crucial for protection and establishment of skin tissue homeostasis. Here we report the discovery of a developmentally programmed process that directs preferential localization of invariant natural killer T (iNKT) cells to the skin for early local homeostatic regulation. We show that iNKT cells are programmed predominantly with a CCR10+skin-homing phenotype during thymic development in infant and young mice. Early skin localization of iNKT cells is critical for proper commensal bacterial colonization and tissue development. Mechanistically, skin iNKT cells provide a local source of transferrin that regulates iron metabolism in hair follicle progenitor cells and helps hair follicle development. These findings provide molecular insights into the establishment and physiological functions of iNKT cells in the skin during early life.