Proton nuclear magnetic resonance studies on brain edema.
Proton nuclear magnetic resonance studies on brain edema.
复制标题
质子核磁共振对脑水肿的研究。
DOI：
10.3171/jns.1982.56.6.0747
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发表时间：
1982
影响因子：
4.1
通讯作者：
K. Yoshizaki
中科院分区：
文献类型：
--
作者：
S. Naruse;Y. Horikawa;C. Tanaka;K. Hirakawa;H. Nishikawa;K. Yoshizaki
本文用脉冲核磁共振技术研究了大鼠正常脑组织和水肿脑组织中的水，测量了水的纵向弛豫时间（T_1）和横向弛豫时间（T_2）。在正常脑中，T1和T2是单一成分，都比纯水中短。T_2延长和分离为一快一慢两种成分是冷损伤和三乙基锡（泰特）所致脑水肿的特征性表现，尽管两种类型脑水肿的病变内容和T_1、T_2值变化的程度存在一定差异。定量分析T1和T2值在其时间过程中与水含量的关系表明，T1的延长是指所检查的组织中水的体积增加，而T2的两个阶段反映了水肿液的分布和含量。从水肿形成过程中T2的慢成分与水含量的分析，证明水肿液的增加是稳定的，并且其含量在TET诱导的水肿形成过程中是恒定的。相反，在冻伤水肿形成过程中，在最初几小时内富含水的水肿液增加，之后富含蛋白质的水肿液增加。质子核磁共振弛豫时间的测量为脑水肿的研究提供了新的思路。
The water in normal and edematous brain tissues of rats was studied by the pulse nuclear magnetic resonance (NMR) technique, measuring the longitudinal relaxation time (T1) and the transverse relaxation time (T2). In the normal brain, T1 and T2 were single components, both shorter than in pure water. Prolongation and separation of T2 into two components, one fast and one slow, were the characteristic findings in brain edema induced by both cold injury and triethyl tin (TET), although some differences between the two types of edema existed in the content of the lesion and in the degree of changes in T1 and T2 values. Quantitative analysis of T1 and T2 values in their time course relating to water content demonstrated that prolongation of T1 referred to the volume of increased water in tissues examined, and that two phases of T2 reflected the distribution and the content of the edema fluid. From the analysis of the slow component of T2 versus water content during edema formation, it was demonstrated that the increase in edema fluid was steady, and its content was constant during formation of TET-induced edema. On the contrary, during the formation of cold-injury edema, water-rich edema fluid increased during the initial few hours, and protein-rich edema fluid increased thereafter. It was concluded that proton NMR relaxation time measurements may provide new understanding in the field of brain edema research.