Alternative promoters influence alternative splicing at the genomic level.
Alternative promoters influence alternative splicing at the genomic level.
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替代启动子在基因组水平上影响替代剪接。
DOI：
10.1371/journal.pone.0002377
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发表时间：
2008-06-18
期刊：
影响因子：
3.7
通讯作者：
Kong, Xiangyin
中科院分区：
文献类型：
--
作者：
Xin, Dedong;Hu, Landian;Kong, Xiangyin
越来越多的实验表明，转录和mRNA加工不是两个独立的事件，而是紧密相连的。发现启动子和转录速率都影响选择性剪接。超过一半的人类基因有替代启动子，但目前还不清楚为什么会有这么多替代启动子，以及它们的生物学作用是什么。在这项研究中，我们探讨是否有一个功能之间的相关性，选择性启动子和选择性剪接的全基因组分析人类和小鼠的基因。我们构建了一个大的数据集的基因与选择性启动子和选择性剪接注释。通过对这些基因的分析，我们发现，与单一启动子的基因相比，具有选择性启动子的基因倾向于表现出选择性剪接，并且，具有更多选择性启动子的基因倾向于具有更多的选择性剪接变体。此外，来自不同选择性启动子的转录物倾向于不同地剪接。因此，在基因组水平上，选择性启动子与选择性剪接正相关。
More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing. More than half of human genes have alternative promoters, but it is still not clear why there are so many alternative promoters and what their biological roles are. In this study, we explored whether there is a functional correlation between alternative promoters and alternative splicing by a genome-wide analysis of human and mouse genes. We constructed a large data set of genes with alternative promoter and alternative splicing annotations. By analyzing these genes, we showed that genes with alternative promoters tended to demonstrate alternative splicing compare to genes with single promoter, and, genes with more alternative promoters tend to have more alternative splicing variants. Furthermore, transcripts from different alternative promoters tended to splice differently. Thus at the genomic level, alternative promoters are positively correlated with alternative splicing.
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