Liver-Derived IGF-I Regulates GH Secretion at the Pituitary Level in Mice.
Liver-Derived IGF-I Regulates GH Secretion at the Pituitary Level in Mice.
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DOI：
10.1210/endo.142.11.8478
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发表时间：
2001-11
期刊：
影响因子：
4.8
通讯作者：
K. Wallenius;Klara Sjo Gren;Xiao-ding Peng;Seungjoon Park;V. Wallenius;Jun-li Liu;M. Umaerus;H. Wennbo;O. Isaksson;L. Frohman;R. Kineman;C. Ohlsson;J. Jansson
中科院分区：
文献类型：
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作者：
K. Wallenius;Klara Sjo Gren;Xiao-ding Peng;Seungjoon Park;V. Wallenius;Jun-li Liu;M. Umaerus;H. Wennbo;O. Isaksson;L. Frohman;R. Kineman;C. Ohlsson;J. Jansson
We have reported that liver-specific deletion of IGF-I in mice (LI-IGF-I−/−) results in decreased circulating IGF-I and increased GH levels. In the present study, we determined how elimination of hepatic IGF-I modifies the hypothalamic-pituitary GH axis to enhance GH secretion. The pituitary mRNA levels of GH releasing factor (GHRF) receptor and GH secretagogue (GHS) receptor were increased in LI-IGF-I−/− mice, and in line with this, their GH response to ip injections of GHRF and GHS was increased. Expression of mRNA for pituitary somatostatin receptors, hypothalamic GHRF, somatostatin, and neuropeptide Y was not altered in LI-IGF-I−/− mice, whereas hypothalamic IGF-I expression was increased. Changes in hepatic expression of major urinary protein and the PRL receptor in male LI-IGF-I−/− mice indicated an altered GH release pattern most consistent with enhanced GH trough levels. Liver weight was enhanced in LI-IGF-I−/− mice of both genders. In conclusion, loss of liver-derived IGF-I enhances GH release by...
