Short Report:: A consideration of primaquine dose adjustment for radical cure of Plasmodium vivax malaria
Short Report:: A consideration of primaquine dose adjustment for radical cure of Plasmodium vivax malaria
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DOI：
10.4269/ajtmh.2000.62.393
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发表时间：
2000-03-01
影响因子：
3.3
通讯作者：
Kurnik, D
中科院分区：
文献类型：
--
作者：
Schwartz, E;Regev-Yochay, G;Kurnik, D
许多地区都报告了间日疟原虫疟疾在标准伯氨喹剂量后复发的情况，最近在撒哈拉以南非洲也有报告。在这份报告中，我们描述了八个事件（五名患者）的治疗失败的非免疫以色列旅行者从埃塞俄比亚返回。对23个疗程伯氨喹每公斤体重剂量的回顾性计算显示，体重较重的患者每公斤总剂量较低。8个失败治疗的平均计算剂量（95% CI）为2.5 +/- 0.3 mg/kg，而15个成功治疗疗程的平均计算剂量为4.4 +/- 0.5 mg/kg。体重调整的给药方案可以防止无意的亚治疗药物失败，从而明显伯氨喹失败。在这些病例中，在接受> 3.5 mg/kg的患者中未观察到复发。应考虑根据体重调整伯氨喹的剂量。对于感染来自埃塞俄比亚的菌株的那些，优选> 3.5 mg/kg的剂量。
Relapse of Plasmodium vivax malaria following standard primaquine dosing has been reported from many areas, and more recently from sub-Saharan Africa. In this report we describe eight episodes tin five patients) of treatment failure in non-immune Israeli travelers returning from Ethiopia. Retrospective calculation of the primaquine dose per kilogram of body weight for 23 treatment courses showed a lower total dose per kilogram in heavier patients. The mean calculated dose (95% CI) in the eight failed treatments was 2.5 +/- 0.3 mg/kg compared with 4.4 +/- 0.5 mg/kg in the 15 successful treatment courses. Weight-adjusted dosing regimens may prevent inadvertent subtherapeutic drug failure, and thus apparent primaquine failure. In these cases, no relapses were observed in those who received > 3.5 mg/kg. Consideration should be given to adjusting the dose of primaquine according to body weight. For those infected by strains from Ethiopia a dose > 3.5 mg/kg is preferable.