Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression -: A double-blind controlled study
Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression -: A double-blind controlled study
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DOI：
10.1001/archpsyc.56.4.315
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发表时间：
1999-04-01
影响因子：
--
通讯作者：
Feinsod, M
中科院分区：
文献类型：
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作者：
Klein, E;Kreinin, I;Feinsod, M
背景：经颅磁刺激（TMS）是一种无创的大脑刺激技术，最近被认为是治疗重度抑郁症的有效方法。我们进行了一项双盲、安慰剂对照研究，以评估慢重复性经颅磁刺激（rTMS）对重度抑郁症患者的疗效。方法：采用双盲设计，将70例重度抑郁症患者（女性53例，男性17例，平均年龄58.7岁，SD 17.2岁）随机分为rTMS组和假rTMS组。在两周的时间内，每天进行10次治疗。在治疗方案完成之前、期间和之后，对抑郁症的严重程度进行盲目评估。结果：所有患者完成第一周治疗，67例患者完成整个治疗方案。与接受假治疗的患者相比，接受rTMS治疗的患者在抑郁评分上有明显更大的改善。在两周结束时，35名患者中有17名接受rTMS治疗，而32名患者中只有8名接受假治疗，他们的抑郁评分改善超过50%。结论：本对照研究为慢速rTMS治疗复发性重度抑郁症患者的短期疗效提供了证据。需要进一步的研究来评估rTMS与电惊厥疗法的疗效，以及这种疗法对重度抑郁症和其他精神疾病的长期疗效。
Background: Transcranial magnetic stimulation (TMS), a noninvasive technique for stimulation of the brain, has recently been suggested to be effective for the treatment of major depression. We conducted a double-blind, placebo-controlled study to assess the efficacy of slow repetitive TMS (rTMS) in patients with major depression.Methods: Seventy patients with major depression (53 women, 17 men; mean age, 58.7 years; SD, 17.2 years) were randomly assigned to receive rTMS or sham rTMS in a double-blind design. Treatment was administered in 10 daily sessions during a 2-week period. Severity of depression was blindly assessed before, during, and after completion of the treatment protocol.Results: All patients completed the first week of treatment and 67 completed the entire protocol. Patients who received rTMS had a significantly greater improvement in depression scores compared with those who received sham treatment. At the end of 2 weeks, 17 of 35 patients in the rTMS group, but only 8 of 32 in the sham-treated group, had an improvement of greater than 50% in their depression ratings.Conclusions: This controlled study provides evidence for the short-term efficacy of slow rTMS in patients with recurrent major depression. Additional studies will be necessary to assess the efficacy of rTMS as compared with electroconvulsive therapy as well as the long-term outcome of this treatment in major depression and possibly other psychiatric disorders.