Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families
Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families
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DOI：
10.1042/bst0310806
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发表时间：
2003-08-01
影响因子：
3.9
通讯作者：
Craven, CJ
中科院分区：
文献类型：
--
作者：
Bingle, CD;Craven, CJ
PLUNC（腭、肺和鼻上皮克隆）是一种小型分泌蛋白，在人类、小鼠和脂肪的口咽和上呼吸道中表达。我们描述了位于 20 号染色体（人类）、2 号染色体（小鼠）或 3 号染色体（大鼠）上的至少 14 个 PLUNC 基因家族。这些快速进化的蛋白质在结构上与脂多糖结合蛋白（LBP）和杀菌/通透性增加蛋白（BPI）相关。在本分析中，我们对该蛋白质家族的比较方面进行了评论，该蛋白质家族可能具有保护上皮表面免受病原微生物侵害的功能。
PLUNC (palate, lung and nasal epithelium clone) is a small, secreted protein that is expressed in the oropharynx and upper airways of humans, mice and fats. We have described a family of at least 14 PLUNC genes localized on chromosome 20 (in humans), 2 (in mice) or 3 (in rats). These rapidly evolving proteins are structurally related to lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI). In the present analysis we comment on the comparative aspects of this protein family, which may function to protect epithelial surfaces from pathogenic micro-organisms.