Evaluation of islet transplantation from non-heart beating donors
Evaluation of islet transplantation from non-heart beating donors
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DOI：
10.1111/j.1600-6143.2006.01499.x
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发表时间：
2006-10-01
影响因子：
8.8
通讯作者：
Matsumoto, S.
中科院分区：
文献类型：
--
作者：
Noguchi, H.;Iwanaga, Y.;Matsumoto, S.
我们用我们的京都胰岛分离方法评价了无心跳供体（NHBDs）的胰岛移植。所有患者移植后C肽均阳性。5名受者的平均HbA（1C）水平从移植时的7.8 ± 0.4%显著改善至目前的5.2 ± 0.2%（p < 0.01）。三名患者没有或一个单一的自身抗体成为胰岛素依赖性，而其他两名患者的双重自身抗体减少了他们的胰岛素需求，但没有成为胰岛素依赖性。在每次移植后，胰岛素非依赖性患者的C肽逐渐增加，而在首次移植后3个月至下一次移植期间未成为胰岛素非依赖性患者的C肽显著降低。三名胰岛素非依赖性患者的β评分是八名患者中最好的。总之，我们的方法使NHBDs有效地用于1型糖尿病患者的胰岛移植是可行的。
We evaluated islet transplantation from non-heart beating donors (NHBDs) with our Kyoto Islet Isolation Method. All patients had positive C-peptide after transplantation. The average HbA(1C) levels of the five recipients significantly improved from 7.8 +/- 0.4% at transplant to 5.2 +/- 0.2% currently (p < 0.01). Three patients with no or a single autoantibody became insulin independent while the other two patients with double autoantibodies reduced their insulin requirement but did not become insulin independent. C-peptide in patients who became insulin-independent gradually increased after each transplantation whereas C-peptide in patients who did not become insulin-independent from 3 months after the first transplantation to the next transplantation dramatically decreased. The beta-score of the three patients who became insulin independent was the best of eight. In conclusion, our method makes it feasible to use NHBDs for islet transplant into type 1 diabetic patients efficiently.