The multifaceted role of natriuretic peptides in metabolic syndrome.
The multifaceted role of natriuretic peptides in metabolic syndrome.
复制标题
DOI：
10.1016/j.biopha.2017.05.136
复制
发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Sanyal AJ
中科院分区：
文献类型：
--
作者：
Santhekadur PK;Kumar DP;Seneshaw M;Mirshahi F;Sanyal AJ
由于全球化和复杂的西方和久坐的生活方式，代谢综合征已成为一个严重的公共卫生挑战。由于高热量食物摄入增加和身体活动减少导致高血压、血脂异常、动脉粥样硬化和胰岛素抵抗，肥胖症在世界范围内显著增加。因此，代谢综合征包括心血管疾病、2型糖尿病、肥胖症和非酒精性脂肪性肝病（NAFLD），最近一些癌症也被认为与这种综合征有关。越来越多的证据表明，利钠肽（NP）参与代谢性疾病的病理生理。利钠肽是心脏激素，其在心脏的心房、心室和内皮中产生。这些肽参与体内水分的稳态控制、钠摄入、钾转运、脂肪细胞中的脂解并调节血压。存在于利钠系统中的三种已知的利钠肽激素是心房利钠肽（ANP）、脑利钠肽（BNP）和C型利钠肽（CNP）。这三种肽主要作为内源性配体发挥作用，主要通过其膜受体如利钠肽受体A（NPR-A）、利钠肽受体B（NPR-B B）和利钠肽受体C（NPR-C）发挥作用，并调节各种生理和代谢功能。本文就利钠肽及其受体的结构、功能及其在代谢综合征中的作用作一综述。
Due to globalization and sophisticated western and sedentary lifestyle, metabolic syndrome has emerged as a serious public health challenge. Obesity is significantly increasing worldwide because of increased high calorie food intake and decreased physical activity leading to hypertension, dyslipidemia, atherosclerosis, and insulin resistance. Thus, metabolic syndrome constitutes cardiovascular disease, type 2 diabetes, obesity, and nonalcoholic fatty liver disease (NAFLD) and recently some cancers are also considered to be associated with this syndrome. There is increasing evidence of the involvement of natriuretic peptides (NP) in the pathophysiology of metabolic diseases. The natriuretic peptides are cardiac hormones, which are produced in the cardiac atrium, ventricles of the heart and the endothelium. These peptides are involved in the homeostatic control of body water, sodium intake, potassium transport, lipolysis in adipocytes and regulates blood pressure. The three known natriuretic peptide hormones present in the natriuretic system are atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and c-type natriuretic peptide (CNP). These three peptides primarily function as endogenous ligands and mainly act via their membrane receptors such as natriuretic peptide receptor A (NPR-A), natriuretic peptide receptor B (NPR-B) and natriuretic peptide receptor C (NPR-C) and regulate various physiological and metabolic functions. This review will shed light on the structure and function of natriuretic peptides and their receptors and their role in the metabolic syndrome.
登录
查看更多内容
影响因子：
82.9
作者：
Buglioni A;Burnett JC Jr
通讯作者：
Burnett JC Jr
影响因子：
4.8
作者：
Dai, YS;Cserjesi, P;Molkentin, JD
通讯作者：
Molkentin, JD
影响因子：
11.4
作者：
Durocher, D;Charron, F;Nemer, M
通讯作者：
Nemer, M
影响因子：
4.1
作者：
Chun, YS;Hyun, JY;Park, JW
通讯作者：
Park, JW
影响因子：
8.2
作者：
Cannon MV;Silljé HH;Sijbesma JW;Khan MA;Steffensen KR;van Gilst WH;de Boer RA
通讯作者：
de Boer RA