Counteraction by Morphine of Stress-Induced Inhibition of Growth Hormone Release in the Rat
Counteraction by Morphine of Stress-Induced Inhibition of Growth Hormone Release in the Rat
复制标题
吗啡对抗应激引起的大鼠生长激素释放抑制
DOI：
10.3181/00379727-177-41923
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发表时间：
1984
影响因子：
--
通讯作者：
Joseph Meites
中科院分区：
文献类型：
--
作者：
Karen P. Briski;Kathleen M. Quigley;Joseph Meites
摘要本研究旨在探讨吗啡（莫尔）对雄性大鼠应激时垂体生长激素（GH）释放的影响。循环GH水平显着降低后，短暂（2分钟）暴露于乙醚，在重复醚化加上抽血，并在连续固定。在所有三种应激条件下，与溶剂处理组相比，全身施用莫尔导致血浆GH水平显著增加。这些结果表明，阿片类药物诱导的刺激GH释放的途径在应激过程中是功能性的，并表明应激的抑制作用不涉及阻断阿片受体刺激GH。因此，目前的研究结果，再加上报告说，中央阿片类神经元的整体活性增强，在压力，支持的观点，即GH的下降是由于压倒性的抑制作用的一个独立的非阿片类机制。然而，莫尔可以明显增加阿片受体的刺激足以抵消这种抑制信号，这意味着应激和阿片类药物可能通过不同的机制影响GH的释放。
Abstract The purpose of this study was to determine the effect of morphine (MOR) administration on pituitary growth hormone (GH) release during stress in the male rat. Circulating GH levels were significantly decreased following a brief (2 min) exposure to ether, during repetitive etherization coupled with blood withdrawal, and during continuous immobilization. Under all three stress conditions, systemic administration of MOR resulted in a significant increase in plasma GH levels compared to the vehicle-treated group. These results indicate that the pathway for opiate-induced stimulation of GH release is functional during stress, and suggest that the suppressive effect of stress does not involve a blockade of opiate receptor stimulation of GH. Thus, the present findings, taken together with reports that the overall activity of central opioid neurons is enhanced during stress, support the view that the decline in GH is due to the overriding inhibitory influence of an independent nonopioid mechanism. However, MOR can apparently increase opiate receptor stimulation sufficiently to counteract this inhibitory signal, implying that stress and the opiates may influence GH release via separate mechanisms.