Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations
Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations
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DOI：
10.1093/toxsci/55.1.24
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发表时间：
2000-05-01
影响因子：
3.8
通讯作者：
Schlesinger, RB
中科院分区：
文献类型：
--
作者：
Driscoll, KE;Costa, DL;Schlesinger, RB
评估空气传播物质的呼吸道毒性通常涉及通过吸入暴露动物。这提供了一条进入宿主的自然途径，因此是将毒物引入肺部的首选方法。然而，由于各种原因，这项技术并不总是被使用，在许多研究中，通过气管将测试材料直接注入肺部作为替代暴露程序。气管内滴注已经得到了足够广泛的应用，以至于毒理学学会吸入专科选择编写这份文件，以总结有关使用这种暴露程序的一些关键问题。尽管与吸入给药相比，滴注给药在物质的分布、清除和保留方面有明显的不同，但对于解决与化学品的呼吸毒性有关的具体问题，滴注给药可能是一种有用且经济有效的程序，只要清楚地理解某些警告并仔细遵守某些指南。
The evaluation of respiratory tract toxicity from airborne materials frequently involves exposure of animals via inhalation. This provides a natural route of entry into the host and, as such, is the preferred method for the introduction of toxicants into the lungs. However, for various reasons, this technique cannot always be used, and the direct instillation of a test material into the lungs via the trachea has been employed in many studies as an alternative exposure procedure. Intratracheal instillation has become sufficiently widely used that the Inhalation Speciality Section of the Society of Toxicology elected to develop this document to summarize some key issues concerning the use of this exposure procedure. Although there are distinct differences in the distribution, clearance, and retention of materials when administered by instillation compared to inhalation, the former can be a useful and cost-effective procedure for addressing specific questions regarding the respiratory toxicity of chemicals, as long as certain caveats are clearly understood and certain guidelines are carefully followed.