An evaluation of the International Diabetes Federation definition of metabolic syndrome in Chinese patients older than 30 years and diagnosed with type 2 diabetes mellitus
An evaluation of the International Diabetes Federation definition of metabolic syndrome in Chinese patients older than 30 years and diagnosed with type 2 diabetes mellitus
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DOI：
10.1016/j.metabol.2006.04.003
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发表时间：
2006-08-01
影响因子：
9.8
通讯作者：
Hu, Renming
中科院分区：
文献类型：
--
作者：
Lu, Bin;Yang, Yehong;Hu, Renming
本研究的目的是在国际糖尿病联合会（IDF）提出的代谢综合征（MS）定义中确定最准确的定义，国家胆固醇教育计划专家小组关于成人高血胆固醇检测、评估和治疗的第三次报告（成人治疗组III [ATP III]）和世界卫生组织（WHO），并使用IDF定义评价腰围的临界点，以最佳地定义中国人群中的MS。采用随机整群抽样的方法，对上海市区1039例30岁以上2型糖尿病患者进行调查，共1008例患者进行分析。研究对象包括体重测量、静息血压、空腹血压和颈动脉粥样硬化测量（包括颈总动脉内膜中层厚度（IMT）和颈动脉斑块）。将IDF定义与其他2种定义进行比较，并根据这些定义对患者的颈动脉粥样硬化进行评估。(1)根据IDF、ATPIII和WHO定义，MS患病率分别为50.0%、55.7%和70.0%。(2)所有参与者中被归类为患有或未患有MS的百分比分别为69.9%（根据IDF和ATPIII定义）和70.2%（根据IDF和WHO定义）。(3)MS患者颈总动脉IMT以IDF定义较WHO和ATP III定义厚，颈动脉斑块百分比以IDF定义较WHO和ATP III定义高。(4)将IDF定义的男性腰围分界点由90 cm修改为85 cm时，新发MS患者颈总动脉IMT较原IDF定义的MS患者颈总动脉IMT增厚。总之，根据IDF、ATP III和WHO定义，MS的患病率分别为50.0%、55.7%和70.0%。与ATPIII和WHO定义相比，IDF定义更能预测中国2型糖尿病患者的心血管疾病风险。根据中国人群的IDF定义，男性腰围的修改截断点（90 - 85 cm）可能更适合预测动脉粥样硬化。(c)2006年爱思唯尔公司All rights reserved.
The objective of the study was to determine the most accurate metabolic syndrome (MS) definition among the definitions proposed by the International Diabetes Federation (IDF), the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III [ATPIII]), and the World Health Organization (WHO) and to evaluate the cutoff point of waist circumference using the IDF definition for optimally defining MS in the Chinese population. One thousand thirty-nine Chinese patients older than 30 years and diagnosed with type 2 diabetes mellitus were investigated by randomized cluster sampling in the Shanghai downtown, and 1008 patients were analyzed in this study. Body mass measurements, resting blood pressure, fasting blood measures, and carotid atherosclerotic measurements including common carotid artery intima-media thickness (IMT) and carotid plaque were investigated. The IDF definition was compared with the other 2 definitions, and the carotid atherosclerosis was evaluated among the patients according to these definitions. (1) The MS prevalence was 50.0%, 55.7%, and 70.0% under the IDF, ATPIII, and WHO definitions, respectively. (2) The percentage of all the participants categorized as either having or not having the MS was 69.9% (under the IDF and ATPIII definitions) and 70.2% (under the IDF and WHO definitions). (3) Common carotid artery IMT of patients with MS determined by the IDF definition was thicker than those determined by the WHO and ATPIII definitions, and the percentage of carotid plaque of patients with MS determined by the IDF definition was greater than those determined by the WHO and ATPIII definitions. (4) When the cutoff point of waist circumference in men determined by the IDF definition was modified from 90 to 85 cm, common carotid artery IMT of the emerging male patients with MS was thicker than that of the male patients with MS determined by the original IDF definition. In conclusion, the prevalence of MS was 50.0%, 55.7%, and 70.0% under the IDF, ATPIII, and WHO definitions, respectively. The preferable IDF definition served as a better predictor of cardiovascular disease risk in the Chinese patients diagnosed with type 2 diabetes mellitus compared with the ATPIII and WHO definitions. The modified cutoff point of waist circumference in men under the IDF definition specific for the Chinese population (from 90 to 85 cm) might be more suitable for predicting atherosclerosis. (c) 2006 Elsevier Inc. All rights reserved.