Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster
Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster
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DOI：
10.1534/genetics.107.084582
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发表时间：
2008-04-01
期刊：
影响因子：
3.3
通讯作者：
Zars, Troy
中科院分区：
文献类型：
--
作者：
LaFerriere, Holly;Guarnieri, Douglas J.;Zars, Troy
果蝇的乙醇敏感性和学习机制之间的特殊遗传相关性可能过分强调了支持这两种行为的共同过程。为了直接挑战这些机制是单一的假设，我们检查了10个新菌株的学习表型。其中5种对乙醇的敏感性增加，另外5种则没有。我们测试了每条谱系的位置记忆和嗅觉记忆，发现了两个新的学习突变。在一种情况下，改变tribbles基因，果蝇的位置记忆显著降低，嗅觉记忆提高，酒精反应正常。在第二种情况下，我们称之为乙醇敏感与低记忆（榆树）的基因突变，地点记忆没有改变，嗅觉记忆急剧下降，对乙醇的敏感性增加。然而，总的来说，我们发现在测试的10个品系中，乙醇敏感性和位置记忆之间没有全面的相关性。此外，乙醇敏感性与嗅觉学习之间存在微弱但不显著的相关性。因此，改变对乙醇的学习和敏感性的突变可以彼此独立地发生，这意味着对乙醇敏感性和学习都重要的一组基因可能是对任何一个过程都重要的基因的一个子集。
The ad hoc genetic correlation between ethanol sensitivity and learning mechanisms in Drosophila could overemphasize a common process supporting both behaviors. To challenge directly the hypothesis that these mechanisms are singular, we examined the learning phenotypes of 10 new strains. Five of these have increased ethanol sensitivity, and the other 5 do not. We tested place and olfactory memory in each of these lines and found two new learning mutations. In one case, altering the tribbles gene, flies have a significantly reduced place memory, elevated olfactory memory, and normal ethanol response. In the second case, mutation of a gene we name ethanol sensitive with low memory (elm), place memory was not altered, olfactory memory was sharply reduced, and sensitivity to ethanol was increased. In sum, however, we found no overall correlation between ethanol sensitivity and place memory in the 10 lines tested. Furthermore, there was a weak but nonsignificant correlation between ethanol sensitivity and olfactory learning. Thus, mutations that alter learning and sensitivity to ethanol can occur independently of each other and this implies that the set of genes important for both ethanol sensitivity and learning is likely a subset of the genes important for either process.