Novel intraoperative online functional mapping of somatosensory finger representations for targeted stimulating electrode placement
Novel intraoperative online functional mapping of somatosensory finger representations for targeted stimulating electrode placement
复制标题
用于靶向刺激电极放置的新型术中体感手指表征在线功能映射
DOI：
10.1101/2020.07.10.20149021
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
N. Crone
中科院分区：
文献类型：
--
作者：
D. McMullen;Tessy M. Thomas;M. Fifer;Daniel Candrea;F. Tenore;Robert W. Nickl;E. Pohlmeyer;Christopher G. Coogan;Luke E. Osborn;Adam Schiavi;Teresa J. Wojtasiewicz;C. Gordon;Adam B. Cohen;N. Ramsey;W. Schellekens;S. Bensmaia;G. Cantarero;P. Celnik;Brock Andrew Wester;W. Anderson;N. Crone
术中定义功能皮层，传统上由神经外科医生执行以保留患者功能，现在可以帮助靶电极植入以恢复功能。脑机接口（BMI）有可能恢复瘫痪患者的上肢运动控制，但需要准确放置记录和刺激电极，以实现假肢的功能控制。除了从记录阵列中解码运动之外，在与手指和指尖感觉相关的皮层区域中精确放置刺激电极可以提供感觉反馈，从而可以改善假手的灵巧控制。在我们的研究中，我们证明了使用一种新的术中在线功能映射（OFM）技术与高密度皮层电图（ECoG）定位手指代表在人类初级躯体感觉皮层。结合传统的术前和术中靶向方法，该技术能够准确植入刺激微电极，这通过植入后手指和指尖感觉的皮质内刺激得到证实。这项工作证明了术中OFM的实用性，并将为人类闭环BMI的未来研究提供信息。
Defining eloquent cortex intraoperatively, traditionally performed by neurosurgeons to preserve patient function, can now help target electrode implantation for restoring function. Brain-machine interfaces (BMIs) have the potential to restore upper-limb motor control to paralyzed patients but require accurate placement of recording and stimulating electrodes to enable functional control of a prosthetic limb. Beyond motor decoding from recording arrays, precise placement of stimulating electrodes in cortical areas associated with finger and fingertip sensations allows for the delivery of sensory feedback that could improve dexterous control of prosthetic hands. In our study, we demonstrated the use of a novel intraoperative online functional mapping (OFM) technique with high-density electrocorticography (ECoG) to localize finger representations in human primary somatosensory cortex. In conjunction with traditional pre- and intraoperative targeting approaches, this technique enabled accurate implantation of stimulating microelectrodes, which was confirmed by post-implantation intra-cortical stimulation of finger and fingertip sensations. This work demonstrates the utility of intraoperative OFM and will inform future studies of closed-loop BMIs in humans.
影响因子：
4
作者：
Kramer, Daniel R.;Lee, Morgan B.;Lee, Brian
通讯作者：
Lee, Brian
影响因子：
6.6
作者：
Krug, Axel;Krach, Soeren;Kircher, Tilo
通讯作者：
Kircher, Tilo