The many ways to make a luminal cell and a prostate cancer cell.
The many ways to make a luminal cell and a prostate cancer cell.
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DOI：
10.1530/erc-15-0195
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发表时间：
2015-12
影响因子：
3.9
通讯作者：
Goldstein AS
中科院分区：
文献类型：
--
作者：
Strand DW;Goldstein AS
Research in the area of stem/progenitor cells has led to the identification of multiple stem-like cell populations implicated in prostate homeostasis and cancer initiation. Given that there are multiple cells that can regenerate prostatic tissue and give rise to prostate cancer, our focus should shift to defining the signaling mechanisms that drive differentiation and progenitor self-renewal. In this article, we will review the literature, present the evidence and raise important unanswered questions that will help guide the field forward in dissecting critical mechanisms regulating stem-cell differentiation and tumor initiation.
