The modified Mosher's method and the sulfoximine method
The modified Mosher's method and the sulfoximine method
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DOI：
10.1246/bcsj.79.965
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发表时间：
2006-07-15
影响因子：
4
通讯作者：
Yabuuchi, Tetsuya
中科院分区：
文献类型：
--
作者：
Kusumi, Takenori;Ooi, Takashi;Yabuuchi, Tetsuya
本文介绍了用改进的Mosher方法测定各种含有仲醇的天然产物的绝对构型。该方法一般适用于仲醇，少数情况下羟基被邻位取代基严重阻碍。并对解决问题的对策进行了阐述。包括最近的发现，即改进的莫舍方法可以用于重水氯仿以外的其他溶剂。本文还介绍了亚磺亚胺法测定手性亚硫醚绝对构型的发展和应用。
This article describes the application of the modified Mosher's method to a variety of natural products possessing a secondary alcohol for determining their absolute configuration. The method is generally applicable to secondary alcohols with a few exceptions where the hydroxy group is seriously hindered by neighboring substituents. Countermeasures to solve the problems are also described. Recent findings that the modified Mosher's method can be used in solvents other than deutero-chloroform are included. Development and application of the sulfoximine method for the determination of the absolute configuration of chiral sulfoxides are also described.