Vibrio cholerae strains with mutations in an atypical type I secretion system accumulate RTX toxin intracellularly
Vibrio cholerae strains with mutations in an atypical type I secretion system accumulate RTX toxin intracellularly
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DOI：
10.1128/jb.186.23.8137-8143.2004
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发表时间：
2004-12-01
影响因子：
3.2
通讯作者：
Satchell, KJF
中科院分区：
文献类型：
--
作者：
Boardman, BK;Satchell, KJF
这项研究表明，霍乱弧菌RTX毒素由rtxB，rtxD，rtxE和WC编码的四组分I型分泌系统（TISS）分泌。RtxB和RtxE中的ATP结合位点突变阻断分泌，表明这种非典型TISS需要两种转运ATP酶，其可能作为异源二聚体发挥作用。
This study shows that the Vibrio cholerae RTX toxin is secreted by a four-component type I secretion system (TISS) encoded by rtxB, rtxD, rtxE, and WC. ATP-binding site mutations in both RtxB and RtxE blocked secretion, demonstrating that this atypical TISS requires two transport ATPases that may function as a heterodimer.