DENTAL-PULP RESPONSE TO BACTERIAL-CELL WALL MATERIAL
DENTAL-PULP RESPONSE TO BACTERIAL-CELL WALL MATERIAL
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DOI：
10.1177/00220345850640080401
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发表时间：
1985-01-01
影响因子：
7.6
通讯作者：
BERGENHOLTZ, G
中科院分区：
文献类型：
--
作者：
WARFVINGE, J;DAHLEN, G;BERGENHOLTZ, G
研究了口腔拟杆菌和小韦荣球菌的脂多糖（LPS）和干酪乳杆菌的细胞壁材料诱导牙髓和植入伤口室中白细胞迁移的能力。使用密封在牙本质中制备的口腔V类腔中的冻干材料对三只成年猴进行挑战。实验开始后8和72 h，在组织学上观察牙髓组织反应。在切割牙本质小管后，细菌材料诱导大多数测试牙齿的牙髓组织中的多形核白细胞（PMN）浸润。在两个时间段，3种细菌供试品的反应相似。局部应用牛血清白蛋白（BSA），作为对照，诱导PMN的积累显着减少。植入大鼠体内的腔室中诱导的渗出液体积和白细胞密度的评估显示出与测试之间的牙髓实验相当的排名（即，细菌）和对照（BSA）材料。数据分析表明，细菌细胞壁的高分子量复合物可能会对刚暴露的牙本质上的蛹组织产生不利影响。
Lipopolysaccharides (LPS) from Bacteroides oralis and Veillonella parvula and cell wall material from Lactobacillus casei were studied for their capacity to induce leukocyte migration in the dental pulp and in an implanted wound chamber. Three adult monkeys were challenged using lyophilized material sealed into buccal Class V cavities prepared in dentin. Pulp tissue responses were observed histologically 8 and 72 h after initiation of the experiment. Subjacent to cut dentinal tubules, bacterial materials induced polymorphonuclear leukocyte (PMN) infiltration in the pulp tissue of the majority of test teeth examined. Responses were similar for the 3 bacterial test materials at both time periods. Topical applications of bovine serum albumin (BSA), used as a control, induced significantly less accumulation of PMN. Assessments of induced exudate volumes and leukocyte densities in chambers implanted in rats showed comparable rankings with pulpal experiment between test (i.e., bacterial) and control (BSA) materials. Analysis of the data indicates that high MW complexes of bacterial cell walls may adversely affect pupal tissue across freshly exposed dentin.