Brachial artery endothelial function is stable across the morning in young men.
Brachial artery endothelial function is stable across the morning in young men.
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DOI：
10.1186/s12947-015-0036-1
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发表时间：
2015-10-05
影响因子：
1.9
通讯作者：
Wallace JP
中科院分区：
文献类型：
--
作者：
Thosar SS;Wiggins CC;Shea SA;Wallace JP
早晨与心血管（CV）风险增加相关，血管内皮功能（VEF）是CV疾病的强预测因子。VEF的昼夜节律已经建立，但VEF的早晨变化没有很好的记录。因此，我们测试了VEF在整个脆弱的早晨时段是否受损。在禁食过夜后，8名健康男性（年龄26.3 ± 3岁）在标准化测试条件下每2小时从0700至1300小时在两个独立的日子进行VEF评估。通过充血性血流介导的扩张（FMD）在肱动脉闭塞5分钟后估计VEF。有没有显着变化，FMD或充血剪切刺激在整个6小时的脆弱期，在任何一天，尽管在这些期间的体力活动和膳食的变化。在这个健康的年轻男性群体中，VEF在发生典型行为（早餐和体力活动）的脆弱早晨期间保持稳定。未来的研究应集中在睡眠，睡眠期间的身体活动和内源性昼夜节律在VEF中的作用。
The morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired across the vulnerable morning period. After overnight fasts, eight healthy men (age 26.3 ± 3 yr) underwent assessments of VEF under standardized testing conditions every 2 h from 0700 to 1300 h on two separate days. VEF was estimated following 5 min brachial artery occlusions by hyperemic flow-mediated dilation (FMD). There was no significant change in FMD or hyperemic shear stimulus across the 6 h vulnerable period on either day, despite changes in physical activity and meals across these periods. In this healthy group of young men, VEF is stable across the vulnerable morning period when typical behaviors occurred (breakfast and physical activity). Future research should focus on the roles of sleep, physical inactivity during sleep and endogenous circadian rhythm in VEF.