Neutral and non-neutral evolution of duplicated genes with gene conversion.

Neutral and non-neutral evolution of duplicated genes with gene conversion.
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DOI:
10.3390/genes2010191
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发表时间:
2011-02-18
期刊:
影响因子:
3.5
通讯作者:
Innan H
Innan H
中科院分区:
生物学3区
文献类型:
--
作者:
Fawcett JA;Innan H

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基因转换是重复基因DNA序列进化的主要突变机制之一。它有助于创造物种内DNA多态性的独特模式和物种间的差异。一个典型的模式是所谓的协同进化,在这种模式中,由于DNA片段的频繁交换,复制品之间的差异在很长一段时间内保持在较低水平。此外,基因转换以各种方式影响重复的DNA进化,特别是在选择操作时。在这里,我们回顾理论模型,以了解在中性和非中性的情况下重复的演变。我们还解释了这些理论如何有助于解释真实的多态性和分歧的数据,通过使用一些有趣的例子。
Gene conversion is one of the major mutational mechanisms involved in the DNA sequence evolution of duplicated genes. It contributes to create unique patters of DNA polymorphism within species and divergence between species. A typical pattern is so-called concerted evolution, in which the divergence between duplicates is maintained low for a long time because of frequent exchanges of DNA fragments. In addition, gene conversion affects the DNA evolution of duplicates in various ways especially when selection operates. Here, we review theoretical models to understand the evolution of duplicates in both neutral and non-neutral cases. We also explain how these theories contribute to interpreting real polymorphism and divergence data by using some intriguing examples.
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