Lipid-lowering effect of carnitine in chronically uremic patients treated with maintenance hemodialysis.
Lipid-lowering effect of carnitine in chronically uremic patients treated with maintenance hemodialysis.
复制标题
肉碱对维持性血液透析治疗的慢性尿毒症患者的降脂作用。
DOI：
10.1093/ajcn/33.7.1489
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
L. Campanacci
中科院分区：
文献类型：
--
作者：
G. Guarnieri;F. Ranieri;G. Toigo;A. Vasile;M. Ciman;V. Rizzoli;M. Moracchiello;L. Campanacci
高脂血症常出现在接受维持性血液透析治疗的慢性尿毒症患者中，并被认为是动脉粥样硬化加速发展的危险因素。血液透析患者肌肉肉毒碱含量低。这种异常可能有助于解释在这些受试者中经常观察到的肌病和心肌病。此外，肉毒碱可能在肾功能衰竭的高胆红素血症中起一定作用。肉毒碱，这是必要的脂肪酸氧化，最近已报道，以降低血清甘油三酯在IV型高脂蛋白血症患者。8例患者在血液透析结束时静脉注射肉毒碱，每周3次。肉毒碱以0.5 g剂量给药8周，然后以1.0 g剂量给药6周。治疗结束时血清甘油三酯显著降低。相比之下，8名接受安慰剂的血液透析患者的血脂没有显著变化。肉毒碱管理不引起任何副作用，除了一些欣快。这些结果表明，肉毒碱可能是有效的治疗透析患者的高甘油三酯血症。
Hypertriglyceridemia is often present in chronically uremic patients treated with maintenance hemodialysis and has been considered a risk factor in the accelerated development of atheroma. Muscle carnitine content is low in hemodialyzed patients. This abnormality may help to explain the myopathy and cardiomyopathy often observed in these subjects. In addition, carnitine might play a role in the hypertriglyceridemia in renal failure. Carnitine, which is necessary for fatty acid oxidation, has been recently reported to lower serum triglycerides in patients with type IV hyperlipoproteinemia. Carnitine was administered intravenously three times weekly at the end of hemodialysis in eight patients. Carnitine was given in 0.5 g doses for 8 weeks and then in 1.0 g doses for 6 additional weeks. There was a significant decrease in serum triglycerides at the end of treatment. In contrast, serum lipids in eight hemodialysis patients receiving placebo did not change significantly. Carnitine administration does not cause any side effect except some euphoria. These results suggest that carnitine may be effective in the treatment of hypertriglyceridemia in dialysis patients.