Exclusion of close linkage of the dopamine transporter gene with schizophrenia spectrum disorders.
Exclusion of close linkage of the dopamine transporter gene with schizophrenia spectrum disorders.
复制标题
排除多巴胺转运蛋白基因与精神分裂症谱系疾病的密切联系。
DOI：
10.1176/ajp.152.1.134
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Crowe,RR
中科院分区：
文献类型：
--
作者：
Persico,AM;Wang,ZW;Black,DW;Andreasen,NC;Uhl,GR;Crowe,RR
ObjectiveInvolvement of genetic factors in the pathogenesis of schizophrenia spectrum disorders has been indicated in twin, adoption, and familial aggregation studies; the pivotal role played by the dopamine transporter in dopaminergic neurotransmission makes it a candidate gene for these disorders. Detection of close linkage between a dopamine transporter marker and schizophrenia spectrum disorders would strongly support the existence of causal relationships between genetic mutations at the dopamine transporter locus and the disease phenotype.MethodThe authors assessed the linkage between this gene and schizophrenia spectrum disorders by using polymorphic dopamine transporter gene markers in 1 56 subjects from 16 multiplex pedigrees with schizophrenia as well as schizophreniform, schizoaffective, and schizotypal disorders and mood-incongruent psychotic depression.ResultsComplete (9= 0.0) linkage to the schizophrenia spectrum was excluded under both dominant and recessive models.ConclusionsThese results indicate that allelic variants at the dopamine transporter locus do not provide major genetic contributions to the etiology of schizophrenia and related disorders in these pedigrees.
