Optimal sparse solution for fluorescent diffuse optical tomography: theory and phantom experimental results
Optimal sparse solution for fluorescent diffuse optical tomography: theory and phantom experimental results
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DOI：
10.1364/ao.46.001679
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发表时间：
2007-04-01
期刊：
影响因子：
1.9
通讯作者：
Adibi, Ali
中科院分区：
文献类型：
--
作者：
Mohajerani, Pouyan;Eftekhar, Ali A.;Adibi, Ali
我们提出了一种方法来准确地定位组织内的小荧光物体使用荧光漫射光学断层扫描（FDOT）。该方法利用组织中荧光团的局部或稀疏性质作为先验信息，大大提高了荧光团分布重建的准确性。这通过最小化包括荧光团分布向量的L1范数的成本函数来实现。使用基于光纤的连续FDOT系统对牛奶体模进行的实验结果表明，该方法能够准确定位体模深处的小型荧光物体。(c)2007年，美国光学学会。
We present a method to accurately localize small fluorescent objects within the tissue using fluorescent diffuse optical tomography (FDOT). The proposed method exploits the localized or sparse nature of the fluorophores in the tissue as a priori information to considerably improve the accuracy of the reconstruction of fluorophore distribution. This is accomplished by minimizing a cost function that includes the L, norm of the fluorophore distribution vector. Experimental results for a milk-based phantom using a fiber-based cw FDOT system demonstrate the capability of this method in accurately localizing small fluorescent objects deep in the phantom. (c) 2007 Optical Society of America.