Relationships of Dietary Histidine and Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study.
Relationships of Dietary Histidine and Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study.
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DOI：
10.3390/nu8070420
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发表时间：
2016-07-11
期刊：
影响因子：
5.9
通讯作者：
Sun CH
中科院分区：
文献类型：
--
作者：
Li YC;Li CL;Qi JY;Huang LN;Shi D;Du SS;Liu LY;Feng RN;Sun CH
我们以前的研究已经证明，组氨酸补充剂显着改善炎症和氧化应激在肥胖妇女和高脂饮食诱导的肥胖大鼠。然而，饮食中组氨酸对一般人群的影响尚不清楚。本研究的目的是通过互联网横断面研究探讨中国北方人群膳食中组氨酸与超重/肥胖和腹型肥胖的关系。共随机招募了2376名参与者，并要求他们完成我们的基于互联网的中国人饮食问卷（IDQC）。随后，随机选择88名超重/肥胖参与者，以探讨可能的机制。与健康对照组相比，饮食组氨酸在超重（p < 0.05）和肥胖（p < 0.01）的男女参与者中显着降低。饮食中组氨酸与总体人群的体重指数（BMI）、腰围（WC）和血压呈负相关，在女性和超重/肥胖参与者中观察到更强的相关性。较高的饮食组氨酸与较低的超重/肥胖和腹部肥胖的患病率相关，特别是在女性中。进一步的研究表明，较高的饮食组氨酸与较低的空腹血糖（FBG）、胰岛素抵抗稳态模型评估（HOMA-IR）、餐后2小时血糖（2 h-PG）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1 β（IL-1β）、白细胞介素-6（IL-6）、C反应蛋白（CRP）、丙二醛（MDA）和vaspin以及较高的谷胱甘肽过氧化物酶（GSH-Px）相关，超氧化物歧化酶（SOD）和脂联素的变化。总之，较高的饮食组氨酸与超重/肥胖受试者的能量摄入、胰岛素抵抗、炎症和氧化应激状态呈负相关，而北方中国成年人的超重/肥胖患病率较低。
Our previous studies have demonstrated that histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women and high-fat diet-induced obese rats. However, the effects of dietary histidine on general population are not known. The objective of this Internet-based cross-sectional study was to evaluate the associations between dietary histidine and prevalence of overweight/obesity and abdominal obesity in northern Chinese population. A total of 2376 participants were randomly recruited and asked to finish our Internet-based dietary questionnaire for the Chinese (IDQC). Afterwards, 88 overweight/obese participants were randomly selected to explore the possible mechanism. Compared with healthy controls, dietary histidine was significantly lower in overweight (p < 0.05) and obese (p < 0.01) participants of both sexes. Dietary histidine was inversely associated with body mass index (BMI), waist circumference (WC) and blood pressure in overall population and stronger associations were observed in women and overweight/obese participants. Higher dietary histidine was associated with lower prevalence of overweight/obesity and abdominal obesity, especially in women. Further studies indicated that higher dietary histidine was associated with lower fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), 2-h postprandial glucose (2 h-PG), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP), malonaldehyde (MDA) and vaspin and higher glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and adiponectin of overweight/obese individuals of both sexes. In conclusion, higher dietary histidine is inversely associated with energy intake, status of insulin resistance, inflammation and oxidative stress in overweight/obese participants and lower prevalence of overweight/obesity in northern Chinese adults.