Correlation of Oxidative and Antioxidative Processes in the Blood of Patients with Cervical Spinal Cord Injury.
Correlation of Oxidative and Antioxidative Processes in the Blood of Patients with Cervical Spinal Cord Injury.
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DOI：
10.1155/2016/6094631
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发表时间：
2016
影响因子：
--
通讯作者：
Kasprzak HA
中科院分区：
文献类型：
--
作者：
Woźniak B;Woźniak A;Mila-Kierzenkowska C;Kasprzak HA
评估颈脊髓损伤（CSCI）对氧化应激参数的影响。该研究在42名CSCI患者（研究组），15名脑震荡患者（对照组II）和30名健康志愿者（对照组I）中进行。研究组在脊髓减压手术前和手术后7天（从CSCI到手术的平均时间：8小时）从贵要静脉采血，对照组仅采血一次。手术前硫代巴比妥酸反应物质（TBARS）和共轭二烯（CD）浓度，谷胱甘肽过氧化物酶（GPx），过氧化氢酶（CAT）和肌酸激酶（CK）活性在研究组高于对照组。所有组的还原型谷胱甘肽浓度相似。超氧化物歧化酶（SOD）在研究组比对照I低16%（P ≤ 0.001）。术后7 d红细胞脂质过氧化产物、GPx和CAT活性均较术前降低（P ≤ 0.001），SOD活性较术前升高25%（P ≤ 0.001）。血浆CK较术前降低34%（P ≤ 0.001），CSCI患者伴有氧化应激。手术和药物治疗有助于恢复氧化-抗氧化平衡。
The effect of cervical spinal cord injury (CSCI) on oxidative stress parameters was assessed. The study was conducted in 42 patients with CSCI (studied group), 15 patients with cerebral concussion, without CSCI (Control II), and 30 healthy volunteers (Control I). Blood was taken from the basilic vein: before and seven days after the spinal cord decompression surgery (mean time from CSCI to surgery: 8 hours) in the studied group and once in the controls. Thiobarbituric acid reactive substances (TBARS) and conjugated dienes (CD) concentrations, and glutathione peroxidase (GPx), catalase (CAT), and creatine kinase (CK) activities before the surgery were higher in the studied group than in the controls. Reduced glutathione concentration was similar in all groups. Superoxide dismutase (SOD) in the studied group was 16% lower (P ≤ 0.001) than in Control I. Lipid peroxidation products, and GPx and CAT activities in erythrocytes seven days after the surgery were lower (P ≤ 0.001), while SOD was 25% higher (P ≤ 0.001) than before the surgery. CK in blood plasma after the surgery was 34% lower (P ≤ 0.001) than before it. CSCI is accompanied by oxidative stress. Surgical and pharmacological treatment helps to restore the oxidant-antioxidant balance.