Role of innate immunity in Helicobacter pylori-induced gastric malignancy.
Role of innate immunity in Helicobacter pylori-induced gastric malignancy.
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DOI：
10.1152/physrev.00039.2009
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发表时间：
2010-07
影响因子：
33.6
通讯作者：
Wilson KT
中科院分区：
文献类型：
--
作者：
Peek RM Jr;Fiske C;Wilson KT
幽门螺杆菌定植于全世界大多数人的体内，随之而来的胃部炎症反应是消化性溃疡和胃癌的最强单一危险因素。然而，只有一小部分被殖民的个体产生了具有临床意义的结果。疾病风险是组合性的，可以通过细菌因素、宿主反应和/或宿主与微生物之间的特定相互作用来改变。幽门螺杆菌定植或毒力所需的几种成分已被确定，它们操纵宿主先天免疫反应的能力将是本次综述的重点。识别增加疾病风险的细菌和宿主介质对生物医学研究人员和临床医生都具有深远的影响，因为这些发现不仅可以提供对炎症致癌作用的机制见解，还可以用于识别幽门螺杆菌感染个体的高风险人群，然后可以将其作为治疗干预的目标。
Helicobacter pylori colonizes the majority of persons worldwide, and the ensuing gastric inflammatory response is the strongest singular risk factor for peptic ulceration and gastric cancer. However, only a fraction of colonized individuals ever develop clinically significant outcomes. Disease risk is combinatorial and can be modified by bacterial factors, host responses, and/or specific interactions between host and microbe. Several H. pylori constituents that are required for colonization or virulence have been identified, and their ability to manipulate the host innate immune response will be the focus of this review. Identification of bacterial and host mediators that augment disease risk has profound ramifications for both biomedical researchers and clinicians as such findings will not only provide mechanistic insights into inflammatory carcinogenesis but may also serve to identify high-risk populations of H. pylori-infected individuals who can then be targeted for therapeutic intervention.
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SABA是幽门螺杆菌血凝素的H.
影响因子：
6.7
作者：
Aspholm, Marina;Olfat, Farzad O.;Norden, Jenny;Sonden, Berit;Lundberg, Carina;Sjostrom, Rolf;Altraja, Siiri;Odenbreit, Stefan;Haas, Rainer;Wadstrom, Torkel;Engstrand, Lars;Semino-Mora, Cristina;Liu, Hui;Dubois, Andre;Teneberg, Susann;Arnqvist, Anna;Boren, Thomas
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期刊：
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影响因子：
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影响因子：
3.4
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影响因子：
29.4
作者：
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DOI：
10.1073/pnas.0502040102
发表时间：
2005-06-28
影响因子：
11.1
作者：
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通讯作者：
Aderem, A