In vivo probe of central cholinergic systems.
In vivo probe of central cholinergic systems.
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中枢胆碱能系统的体内探针。
DOI：
10.1093/geronj/43.6.m158
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Feldman,DS
中科院分区：
文献类型：
--
作者：
Meador,KJ;Loring,DW;Lee,GP;Taylor,HS;Hughes,DR;Feldman,DS
与年龄相关的认知障碍和阿尔茨海默型痴呆与胆碱能系统的改变有关。在本研究中，在健康受试者中进行神经药理学操作，包括：东莨菪碱（抗胆碱能）、东莨菪碱加毒扁豆碱（抗胆碱酯酶）、东莨菪碱加哌甲酯（肾上腺素能）和安慰剂，获得诱发电位和神经心理学测试。东莨菪碱延长了 P3 潜伏期并降低了长潜伏期诱发电位的频谱功率，而不会显着改变早期成分。毒扁豆碱部分逆转了这些影响，但哌醋甲酯却没有。东莨菪碱可减慢运动速度，但东莨菪碱加哌醋甲酯则不会减慢运动速度。胆碱能系统似乎参与 P3 电位的产生或调节，可能继发于胆碱能在选择性注意中的作用。类似的技术可用作中枢胆碱能功能的体内探针，从而作为衰老和疾病的研究和诊断辅助手段。
Age-related cognitive impairments and dementia of Alzheimer type have been linked to alterations in the cholinergic system. In the present study, evoked potentials and neuropsychological testing were obtained in healthy subjects during neuropharmacological manipulations including: scopolamine (anticholinergic), scopolamine plus physostigmine (anticholinesterase), scopolamine plus methylphenidate (adrenergic), and placebo. Scopolamine prolonged P3 latency and reduced spectral power of long latency evoked potentials without significantly altering earlier components. Physostigmine partially reversed these effects, but methylphenidate did not. Motor speed was slowed by scopolamine, but not by scopolamine plus methylphenidate. Cholinergic systems appear to be involved in generation or modulation of the P3 potential, possibly secondary to the cholinergic role in selective attention. Similar techniques may be useful as in vivo probes of central cholinergic function and thus as research and diagnostic aids in aging and disease.