Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation
Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation
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DOI：
10.1111/j.1600-0501.2005.01143.x
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发表时间：
2005-10-01
影响因子：
4.3
通讯作者：
Sewing, A
中科院分区：
文献类型：
--
作者：
Schliephake, H;Aref, A;Sewing, A
本研究的目的是验证骨形态发生蛋白（bone morphogenic protein, BMP2）固定在钛种植体表面可以促进种植体周围骨形成的假设。10只成年雌性猎狐犬在去除全部前磨牙3个月后，在下颌骨植入实验性钛螺钉种植体。在每只动物中评估三种类型的种植体表面：(i)机械钛表面种植体，（ii）胶原i包被种植体，（iii）胶原i、硫酸软骨素（CS）和BMP2包被种植体。5只狗分别在1个月和3个月后通过测量骨-种植体接触（BIC）和新形成的种植体周围骨（BVD）的体积密度，采用组织形态学测量法评估种植体周围骨再生情况。1个月后，两组包被种植体的BIC值没有明显增强，但新形成的种植体周围骨的体积密度明显增加。胶原蛋白与BMP2涂层之间无显著差异。3个月后，与加工表面的种植体相比，胶原蛋白和bmp2包被种植体的BIC均显著增加。与加工表面相比，涂层种植体的种植体周围BVD也显着增加。结论：胶原包膜对牙种植体BIC及种植体周围骨形成有促进作用。在目前的应用中，添加BMP2并不会增加种植体周围骨的形成。
The aim of the present study was to test the hypothesis that immobilization of bone morphogenic protein (BMP2) on the surface of titanium implants can enhance peri-implant bone formation. Ten adult female foxhounds received experimental titanium screw implants in the mandible 3 months after removal of all premolar teeth. Three types of implant surfaces were evaluated in each animal: (i) implants with machined titanium surface, (ii) implants coated with collagen I, (iii) implants coated with collagen I, chondroitin sulphate (CS) and BMP2. Peri-implant bone regeneration was assessed using histomorphometry after 1 and 3 months in five dogs each by measuring bone-implant contact (BIC) and the volume density of the newly formed peri-implant bone (BVD). After 1 month, there was no significant enhancement in BIC values but volume density of the newly formed peri-implant bone was significantly higher in the two groups of coated implants. No significant difference was found between collagen and BMP2 coating. After 3 months, BIC was significantly higher in both collagen and BMP2-coated implants compared with implants with machined surfaces. Peri-implant BVD was also significantly increased in coated implants in comparison with machined surfaces. It was concluded that collagen coating of dental screw implants can enhance BIC and peri-implant bone formation. Addition of BMP2 does not increase peri-implant bone formation in the present application.