Effect of Electro-acupuncture Intervention on Cognition Attention Bias in Heroin Addiction Abstinence-A Dot-probe-based Event-related Potential Study
Effect of Electro-acupuncture Intervention on Cognition Attention Bias in Heroin Addiction Abstinence-A Dot-probe-based Event-related Potential Study
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DOI：
10.1007/s11655-011-0698-y
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发表时间：
2011-04-01
影响因子：
2.9
通讯作者：
Lu Guang-hua
中科院分区：
文献类型：
--
作者：
Jiang Ying-ping;Liu Hao;Lu Guang-hua
目的：研究电针干预前后海洛因依赖者认知注意相关脑功能的变化，探讨成瘾复发的相关神经机制及电针干预的中枢作用。方法：采用事件相关电位技术，以点探针式实验形式记录10例海洛因依赖者(试验组)在执行正面情绪线索、负面情绪线索和海洛因相关线索认知任务时，电针干预前后电极的事件相关电位。分析所选观察点(Fz、Cz、Pz)的P200波幅成分，并与10名健康受试者的P200波幅成分进行比较。结果：电针前，实验组注意于HRC的事件相关电位高于PEC和NEC(P结论：海洛因依赖者对海洛因依赖存在注意偏向，电针干预可显著降低这种偏向，说明电针能有效地抑制海洛因的注意偏向，从而有可能降低复发率。
Objective: To study the changes of cognitive attention-related brain function in the heroin addicts before and after electro-acupuncture (EA) intervention for exploring the concerned neuro-mechanism of addictive relapse and the central action role of EA intervention. Methods: Adopting event-related potential (ERP) technique, the ERP at 64 electrode spots in 10 heroin addicts (test group) were recorded before and after EA intervention with dot-probe experimental form during implementing cognitive task on positive emotional clue (PEG), negative emotional clues (NEC), and heroin-related clue (HRC). The P200 amplitude components on the selected observation points (Fz, Cz, and Pz) were analyzed and compared with those obtained from 10 healthy subjects as the control. Results: Before EA, the ERP of attention on HRC in the test group was higher than that on PEC and NEC (P NEC at Pz. Conclusion: Heroin addicts show attention bias to HAG, which could be significantly reduced by EA intervention, illustrating that EA could effectively inhibit the attention bias to heroin and so might have potential for lowering the relapse rate.