Appendiceal mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma and K-RAS mutation.
Appendiceal mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma and K-RAS mutation.
复制标题
阑尾粘液性囊腺癌，伴有间变性癌壁结节和 K-RAS 突变。
DOI：
10.5152/tjg.2018.17738
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Filiz Özen
中科院分区：
文献类型：
--
作者：
G. Kir;B. Sarbay;B. Girgin;Filiz Özen
壁结节在卵巢和胰腺粘液性囊性肿瘤中是常见的，它们在大体和组织病理学上与肿瘤的粘液成分不同，后者可能是良性或恶性的。恶性壁结节包括间变性癌、透明细胞癌、神经内分泌癌、巨细胞癌、癌肉瘤和肉瘤[1]。在此，我们报告了第一例阑尾粘液性囊腺癌伴多个壁结节，包括两个组成部分均存在K-RAS基因突变状态的未分化癌。
Mural nodules are well-established in ovarian and pancreatic mucinous cystic neoplasms, and they grossly and histopathologically differ from the mucinous component of the tumor, which could be benign or malignant. Malignant mural nodules may include anaplastic carcinoma, clear cell carcinoma, neuroendocrine carcinoma, giant cell carcinoma, carcinosarcoma, and sarcoma (1). Herein, we report the first case of an appendiceal mucinous cystadenocarcinoma with multiple mural nodules comprising anaplastic carcinoma with K-RAS gene mutation status in both components.