REGULATION OF BCL-2 PROTOONCOGENE EXPRESSION DURING NORMAL HUMAN-LYMPHOCYTE PROLIFERATION
REGULATION OF BCL-2 PROTOONCOGENE EXPRESSION DURING NORMAL HUMAN-LYMPHOCYTE PROLIFERATION
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DOI：
10.1126/science.3495884
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发表时间：
1987-06-05
期刊：
影响因子：
56.9
通讯作者：
NOWELL, PC
中科院分区：
文献类型：
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作者：
REED, JC;TSUJIMOTO, Y;NOWELL, PC
bcl-2和c-myc原癌基因与免疫球蛋白重链位点并置，特别是B细胞淋巴瘤，导致其信使RNA的高水平组成性积累。确切地说，bcl-2和c-myc基因的产物如何促进肿瘤发生尚不清楚，但在非肿瘤性淋巴细胞中，在刺激增殖后，c-myc表达被迅速诱导的观察结果提高了这种原癌基因参与控制正常细胞生长的可能性。正常人B和T淋巴细胞经适当的有丝分裂原刺激后，除c-myc外，bcl-2原癌基因也有表达。这些原癌基因表达调控的比较显示出明显的差异，并提供证据表明，与c-myc相比，bcl-2信使RNA的水平主要通过转录机制调节。
The bcl-2 and c-myc proto-oncogenes are brought into juxtaposition with the immunoglobulin heavy chain locus in particular B-cell lymphomas, resulted in high levels of constitutive accumulation of their messenger RNAs. Precisely how the products of the bcl-2 and c-myc genes contribute to tumorigenesis is unknown, but observations that c-myc expression is rapidly induced in nonneoplastic lymphocytes upon stimulation of proliferation raise the possibility that this proto-oncogene is involved in the control of normal cellular growth. In addition to c-myc, the bcl-2 proto-oncogene also was expressed in normal human B and T lymphocytes after stimulation with appropriate mitogens. Comparison of the regulation of the expression of these proto-oncogenes demonstrated marked differences and provided evidence that, in contast to c-myc, levels of bcl-2 messenger RNA are regulated primarily through transcriptional mechanisms.