One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment.
One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment.
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一年的有氧运动改变了轻度认知障碍患者的脑血管舒缩反应。
DOI：
10.1152/japplphysiol.00158.2021
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Zhang,Rong
中科院分区：
文献类型：
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作者：
Tomoto,Tsubasa;Tarumi,Takashi;Chen,JasonN;Hynan,LindaS;Cullum,CMunro;Zhang,Rong
本研究的目的是验证一年有氧运动训练(AET)后脑血管运动反应性(CVMR)的变化与遗忘性轻度认知障碍(MCI)患者的认知表现相关的假设。70名久坐的遗忘型MCI患者被随机分为1年的中等到剧烈强度的AET或拉伸和调理(SAT)干预。采用经颅多普勒测定脑血流速度(CBFV)、平均动脉压(MAP)、二氧化碳分压(EtCO2)等指标评价CVMR。脑血管传导指数(CVCI)由CBFV/MAP计算，CVMR由ΔCBFV/ΔETCO2和ΔCVCI/ΔETCO2计算。采用标准神经心理学测验(CVLT-II和D-KEFS)评定情景记忆和执行功能。以最大摄氧量(V、̇、O2峰值)评价心肺功能。共有37名患者(19名在SAT组，18名在AET组)完成了为期一年的干预和CVMR评估。AET改善V-̇O2峰，增加低碳酸血症CVMR，但降低高碳酸血症CVMR。与SAT相比，AET对认知成绩的影响微乎其微。在两组患者中，CBFV%和CVCI%中低碳酸血症和高碳酸血症的CVMR变化呈负相关(r=−0.741，r=−0.725，P<；0.001)。在AET组中，减弱的高碳酸血症CVMR，而不是增加的低碳酸血症CVMR，与认知测试分数的改善有关。综上所述，1年的AET增加了与遗忘性认知障碍患者认知功能相关的低碳酸血症脑血管代谢率和高碳酸血症脑血管代谢率。一年中强度有氧运动训练改善了心肺功能(V̇O2峰)，增加了低碳酸血症脑血管运动反应性，但与拉伸和锻炼相比，健忘性轻度认知障碍患者的高碳酸血症脑血管代谢性代谢率降低。此外，伴有AET的高碳酸血症CVMR的改变与记忆和执行功能的改善有关。这些发现表明，AET对脑血管功能有影响，这可能有助于阿尔茨海默病高危老年人的认知表现。
The purpose of this study was to test the hypothesis that changes in cerebral vasomotor reactivity (CVMR) after 1-yr aerobic exercise training (AET) are associated with cognitive performances in individuals with amnestic mild cognitive impairment (MCI). Seventy sedentary patients with amnestic MCI were randomized to 1-yr moderate-to-vigorous intensity AET or stretching and toning (SAT) interventions. Cerebral blood flow velocity (CBFV) with transcranial Doppler, mean arterial pressure (MAP) with finapres plethysmograph, and EtCO2with capnography were measured during hyperventilation (hypocapnia) and a modified rebreathing protocol (hypercapnia) to assess CVMR. Cerebrovascular conductance index (CVCi) was calculated by CBFV/MAP, and CVMR by ΔCBFV/ΔEtCO2and ΔCVCi/ΔEtCO2. Episodic memory and executive function were assessed using standard neuropsychological tests (CVLT-II and D-KEFS). Cardiorespiratory fitness was assessed by peak oxygen uptake (V̇o2peak). A total of 37 patients (19 in SAT and 18 in AET) completed 1-yr interventions and CVMR assessments. AET improved V̇o2peak, increased hypocapnic CVMR, but decreased hypercapnic CVMR. The effects of AET on cognitive performance were minimal when compared with SAT. Across both groups, there was a negative correlation between changes in hypocapnic and hypercapnic CVMRs in CBFV% and CVCi% (r= −0.741,r= −0.725,P< 0.001). Attenuated hypercapnic CVMR, but not increased hypocapnic CVMR, was associated with improved cognitive test scores in the AET group. In conclusion, 1-yr AET increased hypocapnic CVMR and attenuated hypercapnic CVMR which is associated cognitive performance in patients with amnestic MCI.NEW & NOTEWORTHYOne-year moderate-to-vigorous intensity aerobic exercise training (AET) improved cardiorespiratory fitness (V̇o2peak), increased hypocapnic cerebral vasomotor reactivity (CVMR), whereas it decreased hypercapnic CVMR when compared with stretching and toning in patients with amnestic mild cognitive impairment (MCI). Furthermore, changes in hypercapnic CVMR with AET were correlated with improved memory and executive function. These findings indicate that AET has an impact on cerebrovascular function which may benefit cognitive performance in older adults who have high risk of Alzheimer’s disease.