Targeting Lipid Metabolism in Liver Cancer
Targeting Lipid Metabolism in Liver Cancer
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DOI：
10.1021/acs.biochem.0c00477
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发表时间：
2020-10-20
期刊：
影响因子：
2.9
通讯作者：
Merched, Aksam
中科院分区：
文献类型：
--
作者：
Alannan, Malak;Fayyad-Kazan, Hussein;Merched, Aksam
癌细胞高度依赖于不同的代谢途径来维持其生存、生长和增殖。脂质代谢不仅为细胞提供能量需求，而且为细胞生长提供原料，为许多致癌途径提供信号分子。脂质主要在肝脏中加工，在该器官的生理以及代谢综合征和肝细胞癌等许多疾病的病理进展中发挥着重要作用。肝细胞癌的进展与炎症和复杂的代谢重编程有关，尽管进行了多年的专门研究，但由于缺乏有效的治疗方法，其预后仍然很差。肝脂代谢缺陷会导致基因表达异常，并重新连接许多参与肿瘤发生和转移的细胞通路，这意味着干扰肿瘤内和周围微环境的脂代谢可能是治疗肝癌的一种新的治疗途径。因此，本文重点介绍了针对脂代谢的药物的最新进展，并在临床前研究和一些正在进行的临床试验中取得了良好的结果。
Cancer cells are highly dependent on different metabolic pathways for sustaining their survival, growth, and proliferation. Lipid metabolism not only provides the energetic needs of the cells but also provides the raw material for cellular growth and the signaling molecules for many oncogenic pathways. Mainly processed in the liver, lipids play an essential role in the physiology of this organ and in the pathological progression of many diseases such as metabolic syndrome and hepatocellular carcinoma (HCC). The progression of HCC is associated with inflammation and complex metabolic reprogramming, and its prognosis remains poor because of the lack of effective therapies despite many years of dedicated research. Defects in hepatic lipid metabolism induce abnormal gene expression and rewire many cellular pathways involved in oncogenesis and metastasis, implying that interfering with lipid metabolism within the tumor and the surrounding microenvironment may be a novel therapeutic approach for treating liver cancer patients. Therefore, this review focuses on the latest advances in drugs targeting lipid metabolism and leading to promising outcomes in preclinical studies and some ongoing clinical trials.