New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice.
New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice.
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DOI：
10.1007/s12016-020-08824-3
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发表时间：
2021-04
影响因子：
9.1
通讯作者：
Fuller B
中科院分区：
文献类型：
--
作者：
Froghi S;Grant CR;Tandon R;Quaglia A;Davidson B;Fuller B
钙是人体中最丰富的矿物质，是许多生理过程的核心，包括免疫系统的激活和维护。研究继续揭示钙信号在免疫系统中的复杂性。也许钙流入细胞的最好理解的机制是钙库操纵的钙进入（SOCE），其通过钙释放激活通道（CRACs）发生。SOCE是激活免疫系统细胞的核心;然而，最近的研究已经证明了其他钙通道的关键作用，包括瞬时受体电位（TRP）通道。在这篇综述中，我们描述了TRP通道在免疫系统中的表达和功能，并概述了与小鼠疾病模型和人类疾病的关联。因此，强调TRP通道在疾病中的重要性并审查其潜力。TRP通道家族是重要的，其成员具有不断增长的细胞过程数量。在免疫系统内，TRP通道参与多种功能，包括T和B细胞受体信号传导和活化、树突细胞的抗原呈递、嗜中性粒细胞和巨噬细胞杀菌活性以及肥大细胞脱粒。毫不奇怪，这些通道与许多病理状况有关，例如炎症性肠道疾病、慢性疲劳综合征和肌痛性脑脊髓炎、动脉粥样硬化、高血压和特应性。
Calcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells is store-operated calcium entry (SOCE), which occurs via calcium release-activated channels (CRACs). SOCE is central to the activation of immune system cells; however, more recent studies have demonstrated the crucial role of other calcium channels, including transient receptor potential (TRP) channels. In this review, we describe the expression and function of TRP channels within the immune system and outline associations with murine models of disease and human conditions. Therefore, highlighting the importance of TRP channels in disease and reviewing potential. The TRP channel family is significant, and its members have a continually growing number of cellular processes. Within the immune system, TRP channels are involved in a diverse range of functions including T and B cell receptor signalling and activation, antigen presentation by dendritic cells, neutrophil and macrophage bactericidal activity, and mast cell degranulation. Not surprisingly, these channels have been linked to many pathological conditions such as inflammatory bowel disease, chronic fatigue syndrome and myalgic encephalomyelitis, atherosclerosis, hypertension and atopy.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
30.5
作者：
Bertin S;Aoki-Nonaka Y;de Jong PR;Nohara LL;Xu H;Stanwood SR;Srikanth S;Lee J;To K;Abramson L;Yu T;Han T;Touma R;Li X;González-Navajas JM;Herdman S;Corr M;Fu G;Dong H;Gwack Y;Franco A;Jefferies WA;Raz E
通讯作者：
Raz E
影响因子：
8
作者：
Brandao, Katherine;Deason-Towne, Francina;Zhao, Xiaoyun;Perraud, Anne-Laure;Schmitz, Carsten
通讯作者：
Schmitz, Carsten
DOI：
10.1007/978-3-319-26974-0_8
发表时间：
2016-01-01
期刊：
CALCIUM ENTRY PATHWAYS IN NON-EXCITABLE CELLS
影响因子：
--
作者：
Berna-Erro, Alejandro;Jardin, Isaac;Rosado, Juan A.
通讯作者：
Rosado, Juan A.
TRPM2离子通道调节幽门螺杆菌感染期间巨噬细胞极化和胃炎。
影响因子：
8
作者：
Beceiro S;Radin JN;Chatuvedi R;Piazuelo MB;Horvarth DJ;Cortado H;Gu Y;Dixon B;Gu C;Lange I;Koomoa DL;Wilson KT;Algood HM;Partida-Sánchez S
通讯作者：
Partida-Sánchez S