Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study.
Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study.
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DOI：
10.1371/journal.pone.0148189
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
CRIC Study Investigators
中科院分区：
文献类型：
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作者：
Amdur RL;Mukherjee M;Go A;Barrows IR;Ramezani A;Shoji J;Reilly MP;Gnanaraj J;Deo R;Roas S;Keane M;Master S;Teal V;Soliman EZ;Yang P;Feldman H;Kusek JW;Tracy CM;Raj DS;CRIC Study Investigators
房颤（AF）是慢性肾脏病（CKD）患者中最常见的持续性心律失常。在这项研究中，我们检查了3，762名慢性肾功能不全队列（CRIC）研究中的CKD成人患者的炎症与AF之间的相关性。在基线时通过自我报告和心电图（ECG）确定AF。基线时测量的白细胞介素（IL）-1、IL-1受体拮抗剂、IL-6、肿瘤坏死因子（TNF）-α、转化生长因子-β、高敏C反应蛋白和纤维蛋白原的血浆浓度。基线时，642例受试者有AF病史，但ECG记录中仅44例有AF。在平均3.7年的随访中，108例受试者发生新发AF。炎症生物标志物与既往AF病史之间无显著相关性。在调整人口统计学特征、共病情况、实验室检查值、超声心动图变量和药物使用后，血浆IL-6水平与基线时AF的存在显著相关（比值比[OR]，1.61; 95%置信区间[CI]，1.21至2.14; P = 0.001）和新发AF（OR，1.25; 95% CI，1.02至1.53; P = 0.03）。总之，血浆IL-6水平是CKD患者AF的独立和一致的预测因子。
Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association between inflammation and AF in 3,762 adults with CKD, enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study. AF was determined at baseline by self-report and electrocardiogram (ECG). Plasma concentrations of interleukin(IL)-1, IL-1 Receptor antagonist, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor-β, high sensitivity C-Reactive protein, and fibrinogen, measured at baseline. At baseline, 642 subjects had history of AF, but only 44 had AF in ECG recording. During a mean follow-up of 3.7 years, 108 subjects developed new-onset AF. There was no significant association between inflammatory biomarkers and past history of AF. After adjustment for demographic characteristics, comorbid conditions, laboratory values, echocardiographic variables, and medication use, plasma IL-6 level was significantly associated with presence of AF at baseline (Odds ratio [OR], 1.61; 95% confidence interval [CI], 1.21 to 2.14; P = 0.001) and new-onset AF (OR, 1.25; 95% CI, 1.02 to 1.53; P = 0.03). To summarize, plasma IL-6 level is an independent and consistent predictor of AF in patients with CKD.