Mechano-Responsive Piezoelectric Nanofiber as an On-Demand Drug Delivery Vehicle
Mechano-Responsive Piezoelectric Nanofiber as an On-Demand Drug Delivery Vehicle
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DOI：
10.1021/acsabm.1c00232
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发表时间：
2021-03-26
影响因子：
4.7
通讯作者：
Nam, Jin
中科院分区：
文献类型：
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作者：
Jariwala, Tanvi;Ico, Gerardo;Nam, Jin
控制药物的生物分布和药代动力学是提高药物疗效和减少药物副作用的关键。为了满足对药物释放时间和药物数量精确控制的需求，我们利用压电聚偏氟乙烯-三氟乙烯（P(VDF-TrFE)）纳米纤维的机械响应性来进行药物传递应用。纳米材料固有的大表面积体积比，以及变型压电特性，使我们能够使用这种材料作为由直接压电效应驱动的超灵敏和机械响应的药物输送平台。利用纳米纤维固有的负zeta电位来静电负载阳离子药物分子，其中表面电位的变化通过外源性机械驱动触发药物分子的释放。我们发现P（VDF-TrFE）纳米纤维的药物释放动力学取决于纤维直径，因此压电性能。在体外和离体模型中，我们进一步证明了药物释放量可以通过施加生理安全的身体冲击波的压力或剂量作为机械刺激来调节。总之，我们证明了压电静电纺纳米纤维在机械响应控制药物释放方面的效用。
The control over biodistribution and pharmacokinetics is critical to enhance the efficacy and minimize the side effects of therapeutic agents. To address the need for an ondemand drug delivery system for precise control over the release time and the quantity of drugs, we exploited the mechano-responsiveness of piezoelectric poly(vinylidene fluoride-trifluroethylene) (P(VDF-TrFE)) nanofibers for drug delivery applications. The large surface area-to-volume ratio inherent to nanomaterials, together with the transformative piezoelectric properties, allowed us to use the material as an ultrasensitive and mechano-responsive drug delivery platform driven by the direct piezoelectric effect. The intrinsic negative zeta potential of the nanofibers was utilized to electrostatically load cationic drug molecules, where surface potential changes by exogenous mechanical actuation trigger the release of drug molecules. We show that the drug release kinetics of the P(VDF-TrFE) nanofibers depends on the fiber diameter, thus piezoelectric properties. We further demonstrated that the drug release quantity can be tuned by the applied pressure or dose of physiologically safe corporeal shockwaves as a mechanical stimulus in in vitro and ex vivo models. Overall, we demonstrated the utility of piezoelectric electrospun nanofibers for mechano-responsive controlled drug release.