Multinuclear MR investigation of the metabolic response of the murine RIF-1 tumor to 5-fluorouracil chemotherapy.
Multinuclear MR investigation of the metabolic response of the murine RIF-1 tumor to 5-fluorouracil chemotherapy.
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小鼠 RIF-1 肿瘤对 5-氟尿嘧啶化疗的代谢反应的多核 MR 研究。
DOI：
10.1002/mrm.1910190228
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发表时间：
1991
影响因子：
3.3
通讯作者：
Ng,TC
中科院分区：
文献类型：
--
作者：
Sijens,PE;Baldwin,NJ;Ng,TC
使用 19 F 和 31 P MR 波谱监测 10 只小鼠中 RIF-1 肿瘤对 5-氟尿嘧啶（单剂量 260 mg 5FU/kg，腹膜内注射）的代谢反应。 19 F MRS 显示肿瘤 5FU 水平持续下降，氟核苷酸 (Fnuc) 信号增加至初始 5FU 水平 50% 的平台值，在前 2 个时间段内。 化疗后h。尽管肿瘤的 31 P MR 光谱没有显示出显着的初始变化，但在随后的几天中 MR 可见肿瘤磷酸盐的总水平下降并且肿瘤 pH 值增加。磷酸盐代谢和肿瘤 pH 值的变化与检测到的氟水平或肿瘤反应无关。然而，治疗前Pi水平、平台Fnuc水平和5FU诱导的肿瘤体积减小显示出显着相关性。这表明19 F和31 P MR波谱都具有预测对5FU化疗的反应的潜力。 © 1991 学术出版社
The metabolic response of the RIF‐1 tumor to 5‐fluorouracil (a single dose of 260 mg 5FU/kg, ip) was monitored in 10 mice using19F and31P MR spectroscopy.19F MRS revealed a continuous drop in tumor 5FU level and an increase in the fluoronucleotide (Fnuc) signal to a plateau value of 50% of the initial 5FU level, during the first 2 h after chemotherapy. Although the31P MR spectra of the tumors showed no significant initial changes, the total level of MR visible tumor phosphate decreased and tumor pH increased during the subsequent days. The changes in phosphate metabolism and tumor pH did not correlate with the detected fluorine levels or tumor response. However, the pretreatment Pi level, the plateau Fnuc level, and the 5FU induced decrease in tumor volume showed significant correlation. The indicates that both19F and31P MR spectroscopy have potential for predicting reponse to 5FU chemotherapy. © 1991 Academic Press, Inc.
神经遗传学：神经系统的遗传学方法
DOI：
--
发表时间：
1979
期刊：
影响因子：
--
作者：
X. Breakefield
通讯作者：
X. Breakefield