Obstetric predictors of placental/umbilical cord blood volume for transplantation
Obstetric predictors of placental/umbilical cord blood volume for transplantation
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DOI：
10.1067/mob.2003.19
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发表时间：
2003-02-01
影响因子：
9.8
通讯作者：
Cabbad, ME
中科院分区：
文献类型：
--
作者：
Jones, J;Stevens, CE;Cabbad, ME
目的：脐带血是一种有效的替代骨髓的造血干细胞来源。然而，所收集的供体血液和细胞含量的量可能不足以在一些成年受体中植入。本研究确定产科因素，影响可回收胎盘脐带血volume.Study设计：一个回顾性分析的因素，获得了直接观察或医疗记录审查有关收获脐带血的体积进行了;这项分析涉及1993年至1999年期间通过纽约市两家医院产科服务捐献胎盘脐带血的9205名母亲的分娩。1999.RESULTS:产科因素，显着影响的总体积的血液收集的分娩途径，引产，脐带绕颈的存在，婴儿出生体重，多胞胎，胎盘重量和劳动力的持续时间。脐带从静脉穿刺部位的长度和脐带血采集的时间长度也影响了回收的体积。母亲种族与脐带血产量相关;白人母亲提供的脐带血数量比非裔美国人或亚洲母亲多。结论：我们的结果证实，为造血干细胞移植收集的剩余胎盘脐带血的体积受到多种因素的影响，这些因素的存在预示着充分收集的可能性。当脐带较长的长度留在胎盘中时，以及胎盘分娩和收集之间的时间较短时，收集的体积可以得到改善。
OBJECTIVE: Umbilical cord blood is an effective alternative to bone marrow as a source of hematopoietic stem cells in transplantation. However, the amount of donor blood and the cell content that are collected may be insufficient for engraftment in some adult recipients. This study identifies obstetric factors that affect retrievable placental cord blood volume.STUDY DESIGN: A retrospective analysis of factors that were obtained by direct observation or medical record review that were related to harvested cord blood volume was conducted; the analysis involved 9205 deliveries from mothers who donated placental cord blood through the obstetric services of two New York City hospitals between 1993 and 1999.RESULTS: Obstetric factors that influenced significantly the total volume of blood that was collected were route of delivery, induction of labor, presence of a nuchal cord, infant birth weight, multiple births, placental weight, and duration of labor. The length of the umbilical cord from the venipuncture site and the length of time to cord blood collection also affected the volume that was retrieved. Maternal ethnicity was associated with cord blood yield; Caucasian mothers provided larger quantities than either African American or Asian mothers.CONCLUSION: Our results confirm that the volume of residual placental cord blood that is collected for hematopoietic stem cell transplantation is influenced by several factors, the presence of which predict the likelihood of an adequate collection. Collected volumes can be improved when a longer length of the cord is left with the placenta and when there is a shorter time between the delivery of the placenta and the collection.